Table 3

Daily symptoms variability over the 3 months period

SymptomsDaily variability of symptomsMeasurement errors over the 3-month periodMeasurement errors over the last 2 weeks
Maximum negative errorMaximum positive errorPredicted errorMaximum negative errorMaximum positive errorPredicted error
Fatigue (/10)0.8 (0.6 to 1.1)−3.0 (−5.0 to −1.0)1.0 (0.0 to 3.0)−1.2 (−2.3 to−0.2)−2.0 (−3.0 to −1.0)0.0 (−1.0 to 1.0)−1.0 (−2.2 to 0.0)
Pain (/10)0.7 (0.5 to 0.9)−3.0 (−4.0 to −2.0)1.0 (0.0 to 2.0)−1.0 (−1.9 to 0.0)−2.0 (−3.0 to −1.0)0.0 (−1.0 to 1.0)−1.1 (−2.1 to – 0.0)
Dryness (/10)0.6 (0.5 to 0.8)−3.0 (−4.0 to −1.0)1.0 (0.0 to 2.0)−1.0 (−2.1 to −0.1)−1.0 (−3.0 to 0.0)0.0 (−2.0 to 1.0)−0.6 (−2.3 to 0.0)
Ocular dryness (/10)0.6 (0.5 to 0.9)−1.0 (−2.0 to −1.0)2.0 (1.0 to 3.0)−0.3 (−0.6 to 0.0)−1.0 (−1.0 to 0.0)0.0 (0.0 to 1.0)−0.2 (−1.0 to 0.3)
Oral dryness (/10)0.6 (0.4 to 0.8)−2.0 (−3.0 to −1.0)1.0 (1.0 to –3.0)−0.3 (−1.1 to 0.2)−1.0 (−2.0 to 0.0)0.0 (0.0 to 1.0)0.0 (−0.8 to0.1)
ESSPRI score (/10)0.5 (0.4 to 0.7)−2.3 (−3 to −1.3)0.7 (0.0 to 1.3)−1.2 (−1.7 to −0.3)−1.7 (−2.7 to −0.7)−0.3 (−1.0 to 0.3)−1.2 (−1.8 to − 0.1)
  • Values are reported as median (IQR). Daily variability of symptoms: the variability of symptoms over time was evaluated on repeated measurements. Absolute error at each measure was computed per patient and per day as the absolute difference between values of the day and mean over the 3-month period. The mean of these differences was then calculated for each patient. Maximum negative error: ‘minimum value collected through the WebApp over the period of interest (3 months or last 2 weeks)’ minus ‘value collected during the final visit’. Maximum positive error: ‘maximum value collected through the WebApp over the period of interest (3 months or last 2 weeks)’ minus ‘value collected during the final visit’. Predicted error: a linear regression model was built for each patient, based on all daily measures (3 months or last 2 weeks), in order to obtain a prediction of the final value; predicted error is ‘the predicted value at month 3’ minus ‘value collected during the final visit’.

  • ESSPRI, EULAR Sjögren's Syndrome Patient Reported Index.