Inflammatory biomarkers according to disease activity in all included patients
| Inactive visits | Subclinical visits | Active visits | Global p value | Inactive versus subclinical | Subclinical versus active | ||||
| n | Value | n | Value | n | Value | ||||
| CRP (mg/L) | 589 | 1 (1–2.51) | 508 | 7.95 (5.18–14.15) | 108 | 48 (18.4–84) | <0.001 | <0.001 | <0.001 |
| SAA (mg/L) | 443 | 2.56 (1.08–4) | 423 | 16.65 (9–44) | 55 | 147 (26.4–422) | <0.001 | <0.001 | <0.001 |
| ESR (mm/hour) | 473 | 8.5 (6–12.5) | 414 | 18 (11–26) | 87 | 25 (15–44) | <0.001 | <0.001 | 0.002 |
| S100A8/A9 (ng/mL) | 157 | 1074.8 (19 451–7740) | 171 | 9266.6 (4017–21 089) | 9 | 55 671 (11 807–75 891) | <0.001 | <0.001 | 0.082 |
| S100A12 (ng/mL) | 172 | 97 (47–201) | 198 | 202 (7–575) | 13 | 1160 (590–2860) | <0.001 | <0.001 | 0.002 |
| Leucocytes (109/L) | 501 | 7.3 (6.35–8.5) | 39 | 8 (6.74–10.9) | 98 | 8.34 (6.8–11.5) | <0.001 | 0.021 | 0.54 |
| Neutrophils (109/L) | 190 | 3.72 (2.86–4.51) | 136 | 4.15 (3.05–5.02) | 42 | 4.85 (3.43–16.05) | <0.001 | 0.012 | 0.013 |
Values are number (%) for categorical variables or median (IQR) for continuous variables.
CRP, C reactive protein; ESR, erythrocyte sedimentation rate; SAA, serum amyloid A.