Visits characteristics and inflammatory biomarkers according to genotype
| Homozygous | Compound heterozygous | Heterozygous | Class III variants | a | b | c | d | e | |
| n | 233 | 201 | 224 | 89 | |||||
| Females | 125 (54) | 93 (42) | 97 (48) | 45 (49) | NS | ND | ND | ND | ND |
| Median number of visits | 7 (2–13) | 3 (1–9) | 5 (2–8) | 4 (2–11) | *** | * | *** | * | NS |
| Inactive/total ratio | 0.33 (0.08–0.6) | 0.56 (0–1) | 0.6 (0.3–0.9) | 0.6 (0–0.9) | *** | NS | *** | *** | NS |
| Subclinical/total | 0.54 (0.2–0.8) | 0.2 (0–0.5) | 0.25 (0–0.57) | 0.27 (0–0.5) | *** | NS | *** | *** | NS |
| Inactive visits | 2 (1–5) | 1 (0–5) | 3 (1–5) | 2 (1–7) | ** | ** | NS | * | NS |
| CRP (mg/L) | 1.2 (1–3) | 1 (0.6–2.6) | 1 (1–2.2) | 1 (1–2.1) | NS | ND | ND | ND | ND |
| SAA (mg/L) | 2.8 (1.19–4.96) | 3 (1.59–3.82) | 2.2 (0.8–3.68) | 2.4 (1.4–3.3) | * | * | NS | ** | NS |
| ESR (mm/hour) | 10 (7.62–15.75) | 8 (6–11) | 8 (5–11) | 8 (6–11) | *** | NS | *** | *** | NS |
| S100A8/A9 (ng/mL) | 7095.2 (3427–14729) | 5788.4 (3176.6–11 446.7) | 2689.7 (1274.86) | 1137 (700–2567) | *** | *** | NS | *** | * |
| S100A12 (ng/mL) | 135 (81–230) | 170 (91–280) | 70 (37–106.11) | 41 (25–110) | *** | *** | NS | *** | * |
| Leucocytes (109/L) | 7.2 (6.18–8.28) | 7.2 (6.25–8.4) | 7.4 (6.54–8.71) | 7.2 (6.4–8.1) | NS | ND | ND | ND | ND |
| Neutrophils (109/L) | 3.72 (2.82–4.59) | 3.92 (2.98–4.41) | 3.81 (2.87–8.42) | 3.5 (2.7–7.4) | NS | ND | ND | ND | ND |
| Subclinical visits | 3 (1–7) | 1 (0–3) | 1 (0–3) | 1 (0–3) | *** | NS | *** | *** | NS |
| CRP (mg/L) | 9.85 (6–16.8) | 7.5 (5–11.65) | 6.5 (3.9–11.35) | 6.6 (3.1–11.3) | *** | NS | ** | *** | NS |
| SAA (mg/L) | 21 (11.48) | 17 (10.12–39.5) | 13.75 (7.5–37.9) | 12.2 (7–38) | * | NS | NS | NS | NS |
| ESR (mm/hour) | 20 (13–28.38) | 17 (11–23.5) | 15 (9.12–24) | 18 (10.5–30) | ** | NS | * | *** | NS |
| S100A8/A9 (ng/mL) | 14 118 (5561–50 850) | 9319 (1870–16 637) | 6100 (3081–13 111) | 2416 (1462–6338.6) | *** | NS | NS | *** | NS |
| S100A12 (ng/mL) | 303 (130–1590) | 219 (111–510) | 140 (57–335) | 58 (34.3–133.1) | *** | NS | NS | * | ** |
| Leucocytes (109/L) | 8 (6.759.2) | 7.12 (6–8.78) | 10 (8.97–12.26) | NA | ND | ND | ND | ND | ND |
| Neutrophils (109/L) | 4.4 (3.3–5.23) | 4.05 (3–4.63) | 4.05 (2.9–5.15) | 3.7 (3–5.2) | NS | ND | ND | ND | ND |
Values are number (%) for categorical variables or median (IQR) for continuous variables.
a: Global p value; b: heterozygous versus compound heterozygous; c: homozygous versus compound heterozygous; d: heterozygous versus homozygous; e: class III variants versus heterozygous.
*P<0.05. **p<0.01. ***p<0.001. Bold values indicate p-value<0.05.
CRP, C reactive protein; ESR, erythrocyte sedimentation rate; NA, not available; ND, not done; NS, not significant; SAA, serum amyloid A.