Regular Article
Preliminary Classification of Nonmalignant B Cell Proliferation in Sjögren's Syndrome: Perspectives on Pathobiology and Treatment Based on an Integrated Clinico-Pathologic and Molecular Study Approach

https://doi.org/10.1006/bcmd.2001.0446Get rights and content

Abstract

ABSTRACT

A classification of nonmalignant lymphoproliferation in Sjögren's syndrome is presented, based on the results of international meetings regarding Sjögren's syndrome-associated lymphomagenesis and on our results of a clinico-pathologic and molecular study and long-term follow-up in well-characterized patients. Sjögren's syndrome pathobiology has similarities to hepatitis C virus-related B-cell lymphoproliferation. Antigen stimulation with the preferential expansion of rheumatoid factor-positive clones and specific immunoglobulin gene expression and recombination represent key biologic events in lymphoproliferation. This classification is based on the couplingof molecular and histological studies and may result in more selective treatment approaches.

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    Communicated by M. Lichtman, M.D., 08/08/01

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    Correspondence and reprint requests to: Salvatore De Vita, M.D., Division of Rheumatology, University of Udine, P.zza S. Maria della Misericordia, 1, 33100 Udine, Italy. E-mail: [email protected].

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