Regular ArticlePreliminary Classification of Nonmalignant B Cell Proliferation in Sjögren's Syndrome: Perspectives on Pathobiology and Treatment Based on an Integrated Clinico-Pathologic and Molecular Study Approach☆
References (54)
- et al.
The development of malignant lymphoma in the course of Sjögren's syndrome
Am. J. Med.
(1964) - et al.
Clinical evolution and morbidity and mortality of primary Sjögren's syndrome
Semin. Arthritis Rheum.
(2000) - et al.
Clinicopathological factors relating malignant lymphoma with Sjögren's syndrome Semin
Arthritis Rheum.
(1996) - et al.
Primary B-cell lymphoma of salivary gland and its relationship to myoepithelial sialadenitis (MesA)
Hum. Pathol.
(1988) - et al.
Salivary gland lymphoid infiltrates associated with lymphoepithelial lesion: A clinical, pathologic, immunophenotypic study
Hum. Pathol.
(1997) A revised European–American classification of lymphoid neoplasm: A proposal from the International Lymphoma Study Group
Blood
(1994)Is clonality equivalent to malignancy: Specifically, is immunoglobulin gene rearrangement diagnostic of malignant lymphoma?
Hum. Pathol.
(1997)- et al.
Regression of primary low-grade B cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori
Lancet
(1993) - et al.
Widespread clonal B cell disorder in Sjögren's syndrome predisposing to Helicobacter pylori-related gastric lymphoma
Gastroenterology
(1996) - et al.
A high incidence of rheumatoid factor idiotype in monoclonal proteins in the patients with Sjögren's syndrome
J. Autoimmunity
(1989)
Clonal salivary gland infiltrates associated with lymphoepithelial sialoadenitis (Sjögren's syndrome) begin as nonmalignant antigen-selected expansions
Blood
Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V (H) genes show frequent use of V1-69 with distinctive CDR3 features
Blood
Salivary gland immunoglobulin and rheumatoid factor synthesis in Sjögren's syndrome. Natural history and response to treatment
Am. J. Med.
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia
Blood
Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia
Blood
The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacements
Immunol. Today
Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy
Lancet
Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome
Arthritis Rheum.
Evidence of lymphoproliferation in the lack of overt lymphoma in Sjögren's syndrome
Clin. Exp. Rheumatol.
Non malignant lymphoproliferation in Sjögren's syndrome: Proposed classification based on integrated clinico-pathologic and molecular studies and follow-up
Ann. Rheum. Dis.
Clonally expanded lymphocytes in the minor salivary glands of Sjögren's syndrome patients without lymphoproliferative disease
Arthritis Rheum.
Analysis of Vh-D-Jh gene transcripts in B cells infiltrating the salivary glands and lymph node tissue of patients with Sjögren's syndrome
Arthritis Rheum.
Oligoclonal non neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia
Arthritis Rheum.
Predictors of lymphoma development in primary Sjögren's syndrome
Arthritis Rheum.
Malignant lymphoma in primary Sjögren's syndrome: A multicenter, retrospective clinical study by the European Concerted Action on Sjögren's syndrome
Arthritis Rheum.
Pathologic feature of lymphoid proliferations of salivary glands: Lymphoepithelial sialadenitis vs low-grade B-cell lymphoma of MALT type
Ann. Otol. Rinol. Laryngol.
Cited by (48)
Lymphomagenesis predictors and related pathogenesis
2021, Journal of Translational AutoimmunityCitation Excerpt :Nevertheless, lymphadenopathy predicts lymphoma in patients with pSS according to several reports [4,34,35,88,90,99]. SG swelling defined as a swelling lasting for at least two months reflects the biologic background of pSS and it is closely linked to the lymphoma evolution [13,98,100–102]. Approximately two third of pSS patients with MALT lymphomas involve the parotid gland with a slow rate of progression [11].
International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome and Sjogren's syndrome)?: The unmet needs and the clinical grey zone in autoimmune disease management
2017, Autoimmunity ReviewsCitation Excerpt :Routine salivary biopsy has a crucial diagnostic and prognostic value in the assessment of SS patients [137,138]. By integrating histopathological data with clinical and molecular findings, different stages of lymphoproliferation with different risk of lymphoma evolution may be identified [139], providing also a potential useful instrument for patient stratification and for the design of SS trials. The assessment of salivary gland secretory function, mainly through the measure of stimulated or unstimulated salivary flow rate, might be useful to stratify SS patients on the basis of their residual secretory potential in order to identify cases with residual salivary function, potential responders to new treatments for what concerns dryness.
Gastrointestinal Involvement in Systemic Vasculitis
2017, Handbook of Systemic Autoimmune DiseasesCitation Excerpt :The cryoglobulinemic vasculitis or syndrome is a systemic vasculitis usually associated with hepatitis C virus (HCV) infection and characterized by nonneoplastic B-cell lymphoproliferation in the large majority of cases, but with an increased risk of B-cell lymphoma development [114–116]. Among the HCV-negative cryoglobulinemic syndrome group, many cases with type II serum mixed cryoglobulinemia (MC) also present Sjögren's syndrome, an autoimmune and lymphoproliferative disorder primarily involving the salivary and lachrymal glands, leading to glandular damage, dysfunction, and sicca syndrome [117–119]. MC syndrome may rarely complicate with life-threatening abdominal vasculitis, possibly involving the stomach and the small and the large bowel (Figs. 16.3A and B) [114,120–123].
Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome
2016, Rheumatic Disease Clinics of North AmericaSjögren's Syndrome-Associated Lymphoma
2016, Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic AspectsClinical picture, outcome and predictive factors of lymphoma in Sjögren syndrome
2015, Autoimmunity Reviews
- ☆
Communicated by M. Lichtman, M.D., 08/08/01
- 2
Correspondence and reprint requests to: Salvatore De Vita, M.D., Division of Rheumatology, University of Udine, P.zza S. Maria della Misericordia, 1, 33100 Udine, Italy. E-mail: [email protected].