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Oral pulsed high-dose dexamethasone for myositis

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Abstract

To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects were mild. At follow-up five responders were still in remission, without ¶medication. Pulsed high-dose ¶dexamethasone seems beneficial in myositis. A larger, prednisone-controlled trial is justified to analyze long-term efficacy.

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Authors and Affiliations

  1. Department of Neurology, University Medical Centre, PO Box 85500, 3508 GA Utrecht, The Netherlands e-mail address: M.F.G.vdMeulen@neuro.azu.nl Tel.: +31-30-2507978, +31-30-2506480 Fax: +31-30-2522782, , , , , , NL

    M. F. G. van der Meulen, J. E. Hoogendijk & J. H. J. Wokke

  2. Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands, , , , , , NL

    M. de Visser

Authors
  1. M. F. G. van der Meulen
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  2. J. E. Hoogendijk
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  3. J. H. J. Wokke
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  4. M. de Visser
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Additional information

Received: 22 March 1999/Received in revised form: 26 July 1999/Accepted: 8 October 1999

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van der Meulen, M., Hoogendijk, J., Wokke, J. et al. Oral pulsed high-dose dexamethasone for myositis. J Neurol 247, 102–105 (2000). https://doi.org/10.1007/PL00007789

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  • DOI: https://doi.org/10.1007/PL00007789

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