Abstract
Traumatic injury as a trigger for the subsequent development of psoriatic arthritis (PsA) has been implicated by several case reports and case series. However, it is still unclear whether trauma is the inciting event or just an incidental finding. It is thought that the interplay of genetic, immunologic, and environmental factors, such as trauma, may trigger the development of PsA. At least two hypotheses of how trauma may be linked to the development of PsA have surfaced and involve a “deep Koebner effect,” the concept of a synovio-entheseal complex and activation of the innate immune system by biomechanical factors. The role of neuropeptides such as substance P and vasoactive intestinal peptide has been highlighted in the synovium after trauma. Better understanding of this phenomenon would shed light into the pathophysiology of Psa and help the development of preventive and therapeutic strategies.
Similar content being viewed by others
References
Moll JM, Wright V (1973) Psoriatic arthritis. Semin Arthritis Rheum 3:55–78
Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H (2006) Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 54(8):2665–2673
Buckley WR, Raleigh RL (1959) Psoriasis with acro-osteolysis. N Engl J Med 261:539–541
Melski JW, Bernhard JD, Stern RS (1983) The Koebner (isomorphic) response in psoriasis. Associations with early age at onset and multiple previous therapies. Arch Dermatol 119(8):655–659
Stankler L (1969) An experimental investigation on the site of skin damage inducing the Koebner reaction in psoriasis. Br J Dermatol 7:534–535
Fitzgerald O, Winchester R (2009) Psoriatic arthritis: from pathogenesis to therapy. Arthritis Res Ther 11:214
Lloyd P, Ryan C, Menter A (2012) Psoriatic arthritis: an update. Arthritis 2012:176298
Kobner H (1876) Aetiologie der Psoriasis. Vjschr Dermatol Syphilis 3:559–561
Sagi L, Trau H (2011) The Koebner phenomenon. Clin Dermatol 29:231–236
Saini R, Tutrone WD, Strober BE (2003) The Köbner phenomenon and psoriatic arthritis. Cutis 72(5):405–406, Review. PubMed PMID: 14655783
Lories RJ, de Vlam K (2012) Is psoriatic arthritis a result of abnormalities in acquired or innate immunity? Curr Rheumatol Rep 14(4):375–382
McGonagle D, Lories RJ, Tan AL, Benjamin M (2007) The concept of a “synovio-entheseal complex” and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond. Arthritis Rheum 56(8):2482–2491
McGonagle D, Conaghan PG, Emery P (1999) Psoriatic arthritis: a unified concept twenty years on. Arthritis & Rheumatism 42(6):1080–1086
McGonagle DG, Helliwell P, Veale D (2012) Enthesitis in psoriatic disease. Dermatology 225:100–109
McGonagle D, Ash Z, Dickie L, McDermott M, Aydin SZ (2011) The early phase of psoriatic arthritis. Ann Rheum Dis 70(Suppl 1):i71–i76
Fearon U, Veale DJ (2001) Pathogenesis of psoriatic arthritis. Clinical & Experimental Dermatology 26(4):333–337
Eedy DJ, Johnston CF, Shaw C, Buchanan KD (1991) Neuropeptides in psoriasis: an immunocytochemical and radioimmunoassay study. J Invest Dermatol 96(4):434–438
Fearon U, Veale DJ (2001) Pathogenesis of psoriatic arthritis. Clin Exp Dermatol 26:333–337
Lotz M, Carson DA, Vaughan JH (1987) Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science 235(4791):893–895
Veale D, Farrell M, Fitzgerald O (1993) Mechanism of joint sparing in a patient with unilateral psoriatic arthritis and a longstanding hemiplegia. Br J Rheumatol 32(5):413–416
Kane D, Lockhart JC, Balint PV, Mann C, Ferrell WR, McInnes IB (2005) Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint). Ann Rheum Dis 64:325–327
Mulherin D, Bresnihan B, FitzGerald O (1995) Digital denervation associated with absence of nail and distal interphalangeal joint involvement in psoriatic arthritis. J Rheumatol 22(6):1211–1212
Scarpa R, Del Puente A, di Girolamo C, della Valle G, Lubrano E, Oriente P (1992) Interplay between environmental factors, articular involvement, and HLA-B27 in patients with psoriatic arthritis. Ann Rheum Dis 51(1):78–79
Punzi L, Pianon M, Bertazzolo N et al (1998) Clinical, laboratory and immunogenetic aspects of post-traumatic psoriatic arthritis: a study of 25 patients. Clin Exp Rheumatol 16(3):277–281
Thumboo J, Uramoto K, Shbeeb MI et al (2002) Risk factors for the development of psoriatic arthritis: a population based nested case control study. J Rheumatol 29(4):757–762
Eder L, Law T, Chandran V et al (2011) Association between environmental factors and onset of psoriatic arthritis in patients with psoriasis. Arthritis Care Res (Hoboken) 63(8):1091–1097
Love TJ, Zhu Y, Zhang Y et al (2012) Obesity and the risk of psoriatic arthritis: a population-based study. Ann Rheum Dis 71(8):1273–1277
Williams KA, Scott JT (1967) Influence of trauma on the development of chronic inflammatory polyarthritis. Ann Rheum Dis 26(6):532–537
Miller JL, Soltani K, Tourtellotte CD (1971) Psoriatic acro-osteolysis without arthritis. A case study. J Bone Joint Surg Am Mar 53(2):371–374
Langevitz P, Buskila D, Gladman DD (1990) Psoriatic arthritis precipitated by physical trauma. J Rheumatol 17(5):695–697
Goupille P, Soutif D, Valat JP (1991) Psoriatic arthritis precipitated by physical trauma. J Rheumatol 18(4):633
Olivieri I, Gemignani G, Christou C, Semeria R, Giustarini S, Pasero G (1991) The triggering role of physical injury in the onset of peripheral arthritis in seronegative spondyloarthropathy. Rheumatol Int 10(6):251–253
Doury P (1993) Psoriatic arthritis with physical trauma. J Rheumatol 20(9):1629
Padula A, Belsito F, Barozzi L et al (1999) Isolated tenosynovitis associated with psoriasis triggered by physical injury. Clin Exp Rheumatol 17(1):103–104
Taylor-Gjevre RM, Nair B, Gjevre J, Leswick D (2012) Trauma and psoriatic arthritis: is there a relationship? Can Fam Physician 58(11):e636–e640
Pattison E, Harrison BJ, Griffiths CE, Silman AJ, Bruce IN (2008) Environmental risk factors for the development of psoriatic arthritis: results from a case–control study. Ann Rheum Dis 67(5):672–676
Disclosures
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hsieh, J., Kadavath, S. & Efthimiou, P. Can traumatic injury trigger psoriatic arthritis? A review of the literature. Clin Rheumatol 33, 601–608 (2014). https://doi.org/10.1007/s10067-013-2436-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-013-2436-7