Abstract
Patients with celiac disease have an increased rate of malignancies that are not limited to lymphomas. Thyroid carcinoma has not previously been associated with celiac disease. However, among a cohort of patients with celiac disease, we identified an increased risk of papillary carcinoma of the thyroid, standard morbidity ratio of 22.52 (95% confidence interval 14.90–34.04; P < .001), compared to United States national surveillance data. These patients were on a gluten-free diet. Only 1 had Hashimoto's thyroiditis, suggesting that mechanisms apart from autoimmune thyroiditis contribute to the increased risk of carcinoma of the thyroid in celiac disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Green PH, Jabri B (2003) Coeliac disease. Lancet 362:383–391
Bai D, Brar P, Holleran S, Ramakrishnan R, Green PH (2005) Effect of gender on the manifestations of celiac disease: Evidence for greater malabsorption in men. Scand J Gastroenterol 40:183–187
Collin P, Kaukinen K, Valimaki M, Salmi J (2002) Endocrinological disorders and celiac disease. Endocr Rev 23:464–483
Holmes GK, Prior P, Lane MR, Pope D, Allan RN (1989) Malignancy in coeliac disease—Effect of a gluten free diet. Gut 30:333–338
Green PH, Fleischauer AT, Bhagat G, Goyal R, Jabri B, Neugut AI (2003) Risk of malignancy in patients with celiac disease. Am J Med 115:191–195
Askling J, Linet M, Gridley G, Halstensen TS, Ekstrom K, Ekbom A (2002) Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 123:1428–1435
Surveillance E, and End Results (SEER) Program (2004) SEER*Stat Database: Incidence-SEER 9 Regs Public-Use. In: National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch. www.seer.cancer.gov.
Singh B, Shaha AR, Trivedi H, Carew JF, Poluri A, Shah JP (1999) Coexistent Hashimoto's thyroiditis with papillary thyroid carcinoma: Impact on presentation, management, and outcome. Surgery 126:1070–1076
Prasad ML, Huang Y, Pellegata NS, de la Chapelle A, Kloos RT (2004) Hashimoto's thyroiditis with papillary thyroid carcinoma (PTC)-like nuclear alterations express molecular markers of PTC. Histopathology 45:39–46
de Visser KE, Eichten A, Coussens LM (2006) Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24–37
Holmes GK, Stokes PL, Sorahan TM, Prior P, Waterhouse JA, Cooke WT (1976) Coeliac disease, gluten-free diet, and malignancy. Gut 17:612–619
Selby WS, Gallagher ND (1979) Malignancy in a 19-year experience of adult celiac disease. Dig Dis Sci 24:684–688
Cooper BT, Holmes GK, Ferguson R, Cooke WT (1980) Celiac disease and malignancy. Medicine (Baltimore) 59:249–261
Holmes GK (1997) Celiac disease and malignancy. J Pediatr Gastroenterol Nutr 24:S20–S23
Peters U, Askling J, Gridley G, Ekbom A, Linet M (2003) Causes of death in patients with celiac disease in a population-based Swedish cohort. Arch Intern Med 163:1566–1572
Schweizer JJ, Oren A, Mearin ML (2001) Cancer in children with celiac disease: A survey of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 33:97–100
Freeman HJ (2000) T cell lymphoma of the thyroid gland in celiac disease. Can J Gastroenterol 14:635–636
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kent, L., McBride, R., McConnell, R. et al. Increased Risk of Papillary Thyroid Cancer in Celiac Disease. Dig Dis Sci 51, 1875–1877 (2006). https://doi.org/10.1007/s10620-006-9240-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10620-006-9240-z