The histopathology of Sjögren's syndrome in labial salivary gland biopsies

https://doi.org/10.1016/0030-4220(74)90417-4Get rights and content

Abstract

Labial salivary gland biopsy specimens from seventy-five patients evaluated for Sjögren's syndrome were examined histologically. Clinically severe cases of Sjögren's syndrome showed the most marked histologic change. Focus score was found to be the most useful histologic index of severity of the disease. Large numbers of plasma cells were found in small foci and mild cases. Plasma cells were decreased in proportion, compared to lymphocytes, in larger foci and severe cases. These observations are discussed in the light of possible mechanisms of tissue damage in this disease.

References (31)

  • T.E.W. Feltkamp et al.

    Antibodies to Salivary Duct Cells, and Other Autoantibodies in Patients With Sjögren's Syndrome and Other Idiopathic Autoimmune diseases

    Clin. Exp. Immunol

    (1968)
  • K. Whaley et al.

    Salivary Duct Autoantibody in Sjögren's Syndrome: Correlation With Focal Sialadenitis in the Labial Mucosa

    Clin. Exp. Immunol

    (1969)
  • L.G. Anderson et al.

    Cellular-Versus-Humoral Autoimmune Responses to Salivary Gland in Sjögren's Syndrome

    Clin. Exp. Immunol

    (1973)
  • G.L. Schall et al.

    Sequential Salivary Scintigraphy in the Evaluation of Xerostomia in Sjögren's Syndrome

    J. A. M. A

    (1971)
  • K.J. Block et al.

    Sjögren's Syndrome: A Clinical Pathological and Serological Study of Sixty-two Cases

    Medicine

    (1965)
  • Cited by (597)

    View all citing articles on Scopus

    This study was supported in part by a research grant from the Veterans Administration.

    Visiting Associate Professor of Oral Pathology, School of Dentistry, University of California at San Francisco. Current address: Royal Dental Hospital of London School of Dental Surgery (University of London), London W.C.2, England.

    ∗∗

    Assistant Professor of Oral Biology, School of Dentistry, University of California at San Francisco.

    ∗∗∗

    Associate Professor of Medicine and Microbiology, School of Medicine, University of California at San Francisco; Chief, Section of Clinical Immunology and Arthritis, Veterans Administration Hospital, San Francisco, Calif.

    ∗∗∗∗

    Research Associate, Veterans Administration Hospital, San Francisco, Calif.

    View full text