American Journal of Obstetrics and Gynecology
ResearchObstetricsMaternal obesity and high-fat diet program offspring metabolic syndrome
Section snippets
Maternal diet and studies
A rat model of maternal obesity was created using a HF diet prior to and through pregnancy and lactation was utilized. Studies were approved by the Animal Research Committee of Harbor-UCLA Medical Research and Education Institute and were in accordance with the American Association for Accreditation of Laboratory Care and National Institutes of Health guidelines.
Sprague Dawley rats (Charles River Laboratories, Inc, Hollister, CA) were housed in a facility with constant temperature and humidity
Pregnancy
Maternal body weight was increased at the initiation of pregnancy as per the experimental model. Both HF and Con dams gained nearly identical amounts of weight during the pregnancy (Figure 1, A). However, there were marked differences immediately following delivery because Con dams experienced a significantly greater weight loss from pregnancy day e20 to postnatal day one (100 ± vs 40 g; Figure 1, B). Among the 4 lactation groups, 3 of the groups demonstrated a similar maternal weight change
Comment
The results of the present study demonstrate a marked impact of maternal obesity/HF diet on offspring body composition and the risk of metabolic syndrome. Importantly, differential effects on offspring phenotype were observed dependent on whether exposure to maternal obesity occurred during pregnancy, during lactation, or both the pregnancy and lactation periods.
Although HF dams were significantly heavier at conception and throughout pregnancy, both HF and Con dams gained similar amounts of
Acknowledgments
We thank Stacy Behare and Linda Day for technical assistance.
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This work was supported by the National Institutes of Health grants R01DK081756 and R01HD054751.
The authors report no conflict of interest.
Cite this article as: Desai M, Jellyman JK, Han G, et al. Maternal obesity and high-fat diet program offspring metabolic syndrome. Am J Obstet Gynecol 2014;211:237.e1-13.