Original articlePrenatal Anxiety Predicts Individual Differences in Cortisol in Pre-Adolescent Children
Section snippets
Subjects
The ALSPAC is a prospective study of women, their partners, and an index child. The 14,541 enrolled pregnancies (from April 1, 1991 to December 31, 1992) represented 85%–90% of the eligible population resident in three health authorities around Bristol, United Kingdom (Golding et al 2001). Of these, 14,138 surviving children (13,995 mothers) are being followed. The average age of the women at pregnancy was 28 years and ranged from 14 to 46 years; less than 5% were younger than 20 years, and
Results
Preliminary analyses indicated that there was the usual and substantial diurnal variation in cortisol levels for each of the 3 days assessed, with close correspondence among diurnal curves for the 3 days (Figure 1). There was not a significant increase in cortisol from awakening to 30 min after awakening in the group as a whole [means (SD): 10.4 (3.2) and 10.2 (4.1), respectively; paired t test, t(69) =.38]. Stability of individual differences in cortisol values across the 3 days was moderate.
Discussion
We found that anxiety in late pregnancy was associated with individual differences in measures of cortisol in pre-adolescents. The link between prenatal anxiety and offspring HPA axis function was strongest at 32 weeks’ gestation and especially robust for awakening cortisol. These results provide the strongest evidence to date that prenatal stress is associated with longer-term impact on the HPA axis of the human offspring, a finding repeatedly demonstrated in animal investigations.
There was
References (52)
- et al.
Maternal anxiety during pregnancy and subsequent infant development
Infant Behav Dev
(2001) - et al.
Current topicThe placental corticotrophin-releasing hormone-adrenocorticotrophin axis
Placenta
(1995) - et al.
Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys
Biol Psychiatry
(2003) - et al.
Fetal response to induced maternal stress
Early Hum Dev
(2003) - et al.
High levels of cortisol among adolescent offspring of parents with bipolar disorderA pilot study
Psychoneuroendocrinology
(2004) - et al.
Maternal stress beginning in infancy may sensitize children to later stress exposureEffects on cortisol and behavior
Biol Psychiatry
(2002) - et al.
Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety of depressive disorders
Biol Psychiatry
(2004) - et al.
Antenatal maternal anxiety is linked with atypical handedness in the child
Early Hum Dev
(2004) - et al.
Placental corticotropin-releasing hormone and the hypercortisolism of pregnancy
Am J Obstet Gynecol
(1994) - et al.
Cortisol concentrations in 12- to 18-month-old infantsStability over time, location, and stressor
Biol Psychiatry
(2003)
Exposure to postnatal depression predicts elevated cortisol in adolescent offspring
Biol Psychiatry
Psychological measures of prenatal stress as predictors of infant temperament
J Am Acad Child Adolesc Psychiatry
Long-term behavioral and neuroendocrine adaptations to adverse early experience
Prog Brain Res
Prenatal stress and long-term consequencesImplications of glucocorticoid hormones
Neurosci Biobehav Rev
Prenatal stress feminizes juvenile play patterns in male rats
Physiol Behav
Cortisol pulsatility and its role in stress regulation and health
Front Neuroendocrinol
Prenatal maternal anxiety and offspring emotionality in the rat
Psychol Rep
The fetal origins of adult disease
Proc R Soc Lond B Biol Sci
A life course approach to chronic disease epidemiologyConceptual models, empirical challenges and interdisciplinary perspectives
Int J Epidemiol
The total score of the Crown-Crisp Experiential IndexA useful and valid measure of psychoneurotic pathology
Br J Med Psychol
Stress and developmentBiological and psychological consequences
Dev Psychopathol
The awakening cortisol responseMethodological issues and significance
Stress
Prenatal stress diminishes the cytokine response of leukocytes to endotoxin stimulation in juvenile rhesus monkeys
J Clin Endocrinol Metab
Detection of postnatal depressionDevelopment of the 10 item Edinburgh Postnatal Depression Scale
Br J Psychiatry
Fetal HPA stress responses to invasive procedures are independent of maternal responses
J Clin Endocrinol Metab
ALSPAC—The Avon Longitudinal Study of Parents and Children. I. Study methodology
Paediatr Perinat Epidemiol
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