Cell Reports
Volume 2, Issue 5, 29 November 2012, Pages 1187-1196
ReportMDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells
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open access
Graphical Abstract
Highlights
► Viral ssRNA, with or without the 5′ VPg peptide, does not induce IFN-α/β ► Synthesis of minus-strand—but not plus-strand—RNA is crucial for MDA5 activation ► The picornavirus RF activates MDA5 both in vitro and in vivo ► MDA5 activation by viral replicative form is independent of the terminal groups of this RNA
Cited by (0)
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These authors contributed equally to this work
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Present address: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
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Present address: Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, PO Box 9101, 6500 HB, The Netherlands
Copyright © 2012 The Authors. Published by Elsevier Inc.