Original articleSystematic reviews and meta-analysesInflammatory Bowel Disease Is Associated With an Increased Risk of Melanoma: A Systematic Review and Meta-analysis
Section snippets
Methods
This systematic review was conducted following guidance provided by the Cochrane Handbook13 and Kanwal and White14 and was reported according to the Meta-analysis Of Observational Studies in Epidemiology guidelines.15
Results
Of 838 potential studies identified, 12 studies fulfilled all inclusion criteria and were included in the meta-analysis.5, 6, 7, 8, 12, 23, 24, 25, 26, 27, 28, 29 These cumulatively reported 179 cases of melanoma in 172,837 patients with IBD (92,208 with CD, 79,360 with UC, and 1269 unclassified). One hospital-based study was excluded because the data were not sufficient to estimate the SIR.30 One study performed in Olmsted County, Minnesota, was published only in abstract form, but additional
Discussion
Unlike nonmelanoma skin cancers, which usually are amenable to local resection and have excellent cure rates and long-term survival, melanoma is associated with greater morbidity and mortality, with prognosis highly dependent on depth of invasion.31 The 10-year survival of patients with tumor depth less than 0.5 mm is 96%, as compared with 54% for patients with tumor depth of 4 to 6 mm.32 Identifying patients at high risk for this disease would allow appropriate surveillance, enabling early
References (40)
- et al.
Systematic reviews and meta-analyses
Clin Gastroenterol Hepatol
(2012) - et al.
Meta-analysis in clinical trials
Control Clin Trials
(1986) - et al.
Can meta-analyses be trusted?
Lancet
(1991) - et al.
GRADE guidelines: 7. Rating the quality of evidence–inconsistency
J Clin Epidemiol
(2011) - et al.
Publication bias in clinical research
Lancet
(1991) - et al.
Cancer risks in Crohn disease patients
Ann Oncol
(2009) - et al.
Increased risk of cancer in ulcerative colitis: a population-based cohort study
Am J Gastroenterol
(1999) - et al.
Crohn's disease and cancer: a population-based cohort study
Gastroenterology
(1994) - et al.
Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County
Clin Gastroenterol Hepatol
(2004) - et al.
Melanoma in immunosuppressed patients
Mayo Clin Proc
(2012)
Malignant melanoma in renal-transplant recipients
Lancet
Cancers with increasing incidence trends in the United States: 1999 through 2008
CA Cancer J Clin
Defining the patient at high risk for melanoma
Int J Dermatol
Nonmelanoma skin cancer in inflammatory bowel disease: a review
Inflamm Bowel Dis
Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease
Gastroenterology
Cancer risk in a population-based cohort of infl ammatory bowel disease
Am J Gastroenterol
Cancer risk in patients with inflammatory bowel disease: a population-based study
Cancer
Extracolonic malignancies in inflammatory bowel disease
Cancer
Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease
Gastroenterology
Biologic treatment of rheumatoid arthritis and the risk of malignancy: analyses from a large US observational study
Arthritis Rheum
Cited by (151)
Cancer in Inflammatory Bowel Disease
2022, Gastroenterology Clinics of North AmericaRisk of Cancer in Inflammatory Bowel Diseases: Umbrella Review and Reanalysis of Meta-analyses
2022, GastroenterologyCitation Excerpt :We used Stata 17.0 software (StataCorp, College Station, TX) and R software (https://www.r-project.org) for the statistical analysis. This umbrella review critically appraised 277 summary effect estimates (CD, 125; UC, 99; and IBDs, 53) derived from 24 published meta-analyses of observational studies,7,8,11,12,29‒48 and AOM, examining the overall and site-specific risk of cancer among patients with IBDs (Figure 1 and Supplementary Tables 1‒3). The publication dates ranged from 2005 to 2021.
Health Care Maintenance in Patients with Crohn's Disease
2022, Gastroenterology Clinics of North AmericaCitation Excerpt :There is a consensus among the ACG preventive guidelines, the European Crohn's and Colitis Organization, and the American College of Obstetrics and Gynecology to perform cervical cancer screening and a Pap smear on an annual basis for immunosuppressed women with IBD.14 IBD in itself increases the risk of melanoma and nonmelanoma skin cancers (NMSC).63,64 Immunosuppressants further increase this risk.
Vedolizumab or Tumor Necrosis Factor Antagonist Use and Risk of New or Recurrent Cancer in Patients With Inflammatory Bowel Disease With Prior Malignancy: A Retrospective Cohort Study
2022, Clinical Gastroenterology and HepatologyClonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease
2021, Journal of Molecular and Cellular Cardiology
Conflicts of interest This author discloses the following: Edward Loftus has consulted for and has received research support from Janssen Biotech, Abbott Laboratories, and UCB Pharma. The remaining authors disclose no conflicts.