Letter to the editorSerum Dkk-1 levels of DISH patients are not different from healthy controls
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The authors declare that they have no conflicts of interest concerning this article.
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Cited by (19)
The role of Dickkopf-1 in joint remodeling and fibrosis: A link connecting spondyloarthropathies and scleroderma?
2017, Seminars in Arthritis and RheumatismCitation Excerpt :The authors suggested that Dkk-1 may play a significant role in the process of new bone formation in DISH. These findings were challenged by a recent cross-sectional study that showed no difference in functional Dkk-1 levels in patients with DISH compared with healthy controls [33]. Therefore, the role of Dkk-1 in the pathogenesis of DISH remains questionable.
Diffuse idiopathic skeletal hyperostosis
2015, Rheumatology: Sixth EditionPathogenesis of hyperostosis: Key role of mesenchymal cells?
2014, Revue du Rhumatisme (Edition Francaise)Vertebral ankylosing hyperostosis (Forestier-Rotés-Quérol disease): What's new?
2013, Revue du Rhumatisme (Edition Francaise)Pathogenesis of hyperostosis: A key role for mesenchymatous cells?
2013, Joint Bone SpineCitation Excerpt :In addition, the lowest DKK-1 levels were associated with the greatest severity of spinal hyperostosis independently from age, sex, bone turnover markers, and bone mineral density [21]. However, another study failed to replicate this finding [22]. Rather than osteoblast dysfunction, abnormal differentiation of osteoblast precursors, most notably mesenchymous stem cells, may be central to the pathogenesis of DISH according to several recent studies (see below).
Diffuse idiopathic skeletal hyperostosis (Forestier-Rotes-Querol disease): What's new?
2013, Joint Bone SpineCitation Excerpt :Serum DKK-1 levels were significantly decreased in 37 patients with DISH (meeting Resnick's definition), and the lowest levels were seen in the patients who had the most extensive ossifications [26]. Another study, however, found no decrease in serum DKK-1 levels in 27 patients with DISH compared to 26 healthy controls [27]. The issue is therefore unresolved.