Clinical Presentation of Osteoarthritis in General Practice: Determinants of Pain in Italian Patients in the AMICA Study
Section snippets
Patients and Methods
The general framework of AMICA and a number of its descriptive results are described in an accompanying article (6). The data reported here relate to 2764 general practitioners (GPs) who were asked to enroll 10 consecutive patients each with OA of the hand, hip, and knee diagnosed according to the American College of Rheumatology (ACR) clinical criteria (7, 8, 9).
Results
The median age of the patient population as a whole was 70 years (range 50 to 104 years): 70 years (range 50 to 104 years) for women and 70 years (range 50 to 97 years) for men. Figure 1 shows the age and sex distribution by OA location. The mean disease duration was 8.3 ± 7.10 years, and the median age at symptom onset was 60 years (range 20 to 95 years).
Discussion
This study involved a very large number of patients seen by GPs for pain associated with OA at different locations. In Italy, each GP cares for a limited number of National Health Care subjects (generally 1000 to 1500). Virtually every resident of Italy is registered with a GP, who has no right to select patients (10), thus making our sample representative of Italian OA patients seeking a GP's help. This group is obviously not representative of the general population of OA patients, because
References (26)
- et al.
Value of epidemiological research for clinical practice
Best Pract Res Clin Rheumatol
(2002) - et al.
Obesity, overweight and patterns of osteoarthritis
J Clin Epidemiol
(2000) The epidemiology of rheumatoid arthritis
Rheum Dis Clin North Am
(2001)- et al.
Educational attainment and osteoarthritis: differential associations with radiographic changes and symptoms reporting
J Clin Epidemiol
(1992) - Petersson IF, Jacobsson LTH. Osteoarthritis of the peripheral joints. Best Pract Res Clin Rheumatol...
- et al.
Prevalence of symptomatic hand osteoarthritis in community-dwelling older persons: the ICARe Dicomano study
Osteoarthritis Cart
(2000) The economics of osteoarthritis
- et al.
A multicentric study of annual costs of knee osteoarthritis in Italy
Arthritis Rheum
(2001) - et al.
Genetic influence on osteoarthritis in women: a twin study
Br Med J
(1996) - et al.
The characteristics of symptomatic osteoarthritis in general and specialist practice in Italy: design and methods of the AMICA study
Semin Arthritis Rheum
(2005)
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand
Arthritis Rheum
Development of criteria for the classification and reporting of osteoarthritisClassification of osteoarthritis of the knee
Arthritis Rheum
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip
Arthritis Rheum
Cited by (54)
Presence of comorbidities and prognosis of clinical symptoms in knee and/or hip osteoarthritis: A systematic review and meta-analysis
2018, Seminars in Arthritis and RheumatismCitation Excerpt :A total of 794 citations were screened. Twenty-six studies [20–45] were deemed eligible for an assessment of methodological quality, and, of those, 17 citations [21,28–34,36–44] were ultimately included in meta-analysis. The flowchart, including reasons for exclusion, is depicted in Figure 1.
Type 2 diabetes and osteoarthritis: A systematic review and meta-analysis
2016, Journal of Diabetes and its ComplicationsCitation Excerpt :A study from the AMICA cohort had proxy outcomes of pain on the visual analog scale and use of non-steroidal anti-inflammatory drugs, while the Horn study employed osteophytes as their outcome. Given that these outcomes did not meet our inclusion criteria they were excluded (Cimmino, Sarzi-Puttini, Scarpa, et al., 2005). The risk ratios from the Andrianakos and Sturmer studies were updated following communication with those authors.
Characterization of Knee Osteoarthritis in Latin America. A Comparative Analysis of Clinical and Health Care Utilization in Argentina, Brazil, and Mexico
2014, Reumatologia ClinicaCitation Excerpt :Comparisons between countries yielded some interesting differences in demographic characteristics, health care utilization, and some clinical and therapeutic features. This should not be unexpected since previous studies have linked the characteristics of knee OA to ethnicity, living conditions, and access to care.14,20,35,37–40,55–60 As consequence the fragmentation of the health system in Latin America, only a variable percentage of the population is either fully or partially covered by the state.
Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis
2011, Osteoarthritis and CartilageSafety issues in the development of treatments for osteoarthritis: Recommendations of the Safety Considerations Working Group
2011, Osteoarthritis and CartilageCitation Excerpt :In addition there is an associated increased risk of type II diabetes, with its own attendant CV risks. Other common comorbidities in the OA population include chronic obstructive pulmonary disease (COPD), peptic ulcer and other GI diseases, increased risk of obesity and metabolic syndrome and increased incidence of CV disease with increasing age, impairment in renal function and osteoporosis11,58,59. Thus, it is important that novel therapies under development include drug–drug interaction studies in this patient population as well as information regarding instability in blood pressure, blood glucose, and/or renal function during RCTs – and that CV events be carefully surveilled.
Efficacy and Safety of Naproxcinod in Patients with Osteoarthritis of the Knee: A 53-Week Prospective Randomized Multicenter Study
2011, Seminars in Arthritis and Rheumatism