AdherenceMedication Adherence of Patients with Selected Rheumatic Conditions: A Systematic Review of the Literature
Section snippets
Identification and Selection of Articles
A MEDLINE search of English language literature was performed to identify studies published between January 1, 1985 and November 30, 2007 that evaluated adherence, compliance, or persistence of medications for the treatment of rheumatic conditions. The following key words were used as search terms: (patient compliance or adherence or persistence or discontinuation or switching) and (ankylosing spondylitis, or arthritis, or gout, or psoriatic arthritis, or polymyalgia rheumatica, or rheumatoid
Characteristics of the Studies
The majority of studies focused on the treatment of rheumatoid arthritis (Table 1). There were 4 or fewer studies examining adherence in conditions including juvenile idiopathic arthritis (14, 24), polymyalgia rheumatica (25), systemic lupus erythematosus (26, 27, 28, 29), and gout (7, 25, 30). The most common medications studied were nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic agents (DMARDs). These studies employed a variety of study designs to assess
Discussion
This systematic review of the literature is the first to examine the current state of knowledge regarding the use of medications for the treatment of selected chronic inflammatory rheumatic conditions. Overall there were 20 studies that fulfilled criteria to be included in the review, the majority of which were focused on the treatment of rheumatoid arthritis. Many of the studies focused on treatments that are not commonly used today, including D-penicillamine and chronic high-dose salicylates.
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Cited by (0)
Drs. Harrold and Andrade are investigators in the HMO Research Network Center for Education and Research on Therapeutics (Agency for Healthcare Research and Quality HS10391). Dr. Harrold was supported by Grant Number K23AR053856 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Arthritis and Musculoskeletal and Skin Diseases or the National Institutes of Health.