Elsevier

Vaccine

Volume 29, Issue 32, 18 July 2011, Pages 5195-5202
Vaccine

A randomized, double-blind trial to evaluate immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given concomitantly with trivalent influenza vaccine in adults aged ≥65 years

https://doi.org/10.1016/j.vaccine.2011.05.031Get rights and content
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open access

Abstract

This randomized, double-blind study evaluated concomitant administration of 13-valent pneumococcal conjugate vaccine (PCV13) and trivalent inactivated influenza vaccine (TIV) in adults aged ≥65 years who were naïve to 23-valent pneumococcal polysaccharide vaccine. Patients (N = 1160) were randomized 1:1 to receive PCV13 + TIV followed by placebo, or Placebo + TIV followed by PCV13 at 0 and 1 months, with blood draws at 0, 1, and 2 months. Slightly lower pneumococcal serotype-specific anticapsular polysaccharide immunoglobulin G geometric mean concentrations were observed with PCV13 + TIV relative to PCV13. Concomitant PCV13 + TIV demonstrates acceptable immunogenicity and safety compared with either agent given alone.

Keywords

13-Valent pneumococcal conjugate vaccine
Europe
Immunogenicity
Safety

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