Abstract
A STUDY of human lymphocyte phenotypes in unrelated Caucasian individuals with ankylosing spondylitis has revealed a striking similarity in their antigenic pattern. The lymphocytes of fifty such patients, when tested against a panel of twenty-six different specific typing sera, using a two stage lymphocytotoxicity micro-method, were shown to have in common either the antigen HL-A27 (96%) or the antigen W5 (4%). This remarkably high frequency of the antigen HL-A27 compares with the incidence of 5–6% of this antigen in random Caucasian populations.
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CAFFREY, M., JAMES, D. Human Lymphocyte Antigen Association in Ankylosing Spondylitis. Nature 242, 121 (1973). https://doi.org/10.1038/242121a0
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DOI: https://doi.org/10.1038/242121a0
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