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The NIH Roadmap Epigenomics Mapping Consortium

The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease.

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Figure 1: Layers of genome organization.

B. Wong

Figure 2: Portal for the NIH Roadmap Epigenomics Mapping Consortium.

References

  1. Altshuler, D., Daly, M.J. & Lander, E.S. Science 322, 881–888 (2008).

    Article  CAS  Google Scholar 

  2. Bird, A. Nature 447, 396–398 (2007).

    Article  CAS  Google Scholar 

  3. Feinberg, A.P. Nature 447, 433–440 (2007).

    Article  CAS  Google Scholar 

  4. Jaenisch, R. & Bird, A. Nat. Genet. 33 Suppl, 245–254 (2003).

    Article  CAS  Google Scholar 

  5. Jones, P.A. & Baylin, S.B. Cell 128, 683–692 (2007).

    Article  CAS  Google Scholar 

  6. Kouzarides, T. Cell 128, 693–705 (2007).

    Article  CAS  Google Scholar 

  7. Bernstein, B.E., Meissner, A. & Lander, E.S. Cell 128, 669–681 (2007).

    Article  CAS  Google Scholar 

  8. Fraser, P. & Bickmore, W. Nature 447, 413–417 (2007).

    Article  CAS  Google Scholar 

  9. Zaratiegui, M., Irvine, D.V. & Martienssen, R.A. Cell 128, 763–776 (2007).

    Article  CAS  Google Scholar 

  10. Schwartz, Y.B. & Pirrotta, V. Nat. Rev. Genet. 8, 9–22 (2007).

    Article  CAS  Google Scholar 

  11. Grewal, S.I. & Moazed, D. Science 301, 798–802 (2003).

    Article  CAS  Google Scholar 

  12. Henikoff, S. Nat. Rev. Genet. 9, 15–26 (2008).

    Article  CAS  Google Scholar 

  13. Jirtle, R.L. & Skinner, M.K. Nat. Rev. Genet. 8, 253–262 (2007).

    Article  CAS  Google Scholar 

  14. Hess, J.L. Crit. Rev. Eukaryot. Gene Expr. 14, 235–254 (2004).

    Article  CAS  Google Scholar 

  15. Hansen, R.S. et al. Proc. Natl. Acad. Sci. USA 96, 14412–14417 (1999).

    Article  CAS  Google Scholar 

  16. Dalgliesh, G.L. et al. Nature 463, 360–363 (2010).

    Article  CAS  Google Scholar 

  17. Batty, N., Malouf, G. G. & Issa, J. P. Cancer Lett. 280, 192–200 (2009).

    Article  CAS  Google Scholar 

  18. Birney, E. et al. Nature 447, 799–816 (2007).

    Article  CAS  Google Scholar 

  19. Heintzman, N.D. et al. Nature 459, 108–112 (2009).

    Article  CAS  Google Scholar 

  20. Eckhardt, F. et al. Nat. Genet. 38, 1378–1385 (2006).

    Article  CAS  Google Scholar 

  21. Meissner, A. et al. Nature 454, 766–770 (2008).

    Article  CAS  Google Scholar 

  22. Cokus, S.J. et al. Nature 452, 215–219 (2008).

    Article  CAS  Google Scholar 

  23. Barski, A. et al. Cell 129, 823–837 (2007).

    Article  CAS  Google Scholar 

  24. Hesselberth, J.R. et al. Nat. Methods 6, 283–289 (2009).

    Article  CAS  Google Scholar 

  25. Mikkelsen, T.S. et al. Nature 448, 553–560 (2007).

    Article  CAS  Google Scholar 

  26. Lister, R. et al. Nature 462, 315–322 (2009).

    Article  CAS  Google Scholar 

  27. Toronto International Data Release Workshop Authors Nature 461, 168–170 (2009).

  28. Suzuki, M.M. & Bird, A. Nat. Rev. Genet. 9, 465–476 (2008).

    Article  CAS  Google Scholar 

  29. Satterlee, J. Nat. Biotechnol. 28, 1039–1044 (2010).

    Article  CAS  Google Scholar 

  30. Frazer, K.A. et al. Nature 449, 851–861 (2007).

    Article  CAS  Google Scholar 

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Acknowledgements

We thank R. Waterland, C. Epstein, N. Shoresh and all consortium members, as well as the NIH Epigenomics Implementation Group, for discussions and feedback in the drafting of this document.

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Correspondence to Bradley E Bernstein.

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Bernstein, B., Stamatoyannopoulos, J., Costello, J. et al. The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol 28, 1045–1048 (2010). https://doi.org/10.1038/nbt1010-1045

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