Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Between Bedside and Bench
  • Published:

Understanding Local Macrophage Phenotypes In Disease: Shape-shifting macrophages

Macrophages are responsive to local tissue signals and alter their phenotypes accordingly. In disease tissues this means that macrophage phenotypes may change with disease progression, exacerbating or facilitating the resolution of the pathology.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The plasticity of macrophages.

Marina Corral Spence / Nature Publishing Group

References

  1. Murray, P.J. et al. Immunity 41, 14–20 (2014).

    Article  CAS  Google Scholar 

  2. Davies, L.C., Jenkins, S.J., Allen, J.E. & Taylor, P.R. Nat. Immunol. 14, 986–995 (2013).

    Article  CAS  Google Scholar 

  3. Okabe, Y. & Medzhitov, R. Cell 157, 832–844 (2014).

    Article  CAS  Google Scholar 

  4. Rosas, M. et al. Science 344, 645–648 (2014).

    Article  CAS  Google Scholar 

  5. Gosselin, D. et al. Cell 159, 1327–1340 (2014).

    Article  CAS  Google Scholar 

  6. Lavin, Y. et al. Cell 159, 1312–1326 (2014).

    Article  CAS  Google Scholar 

  7. Qian, B.Z. & Pollard, J.W. Cell 141, 39–51 (2010).

    Article  CAS  Google Scholar 

  8. Sica, A. & Mantovani, A. J. Clin. Invest. 122, 787–795 (2012).

    Article  CAS  Google Scholar 

  9. Lewis, C.E. & Pollard, J.W. Cancer Res. 66, 605–612 (2006).

    Article  CAS  Google Scholar 

  10. Movahedi, K. et al. Cancer Res. 70, 5728–5739 (2010).

    Article  CAS  Google Scholar 

  11. Franklin, R.A. et al. Science 344, 921–925 (2014).

    Article  CAS  Google Scholar 

  12. Wang, Y.C. et al. Cancer Res. 70, 4840–4849 (2010).

    Article  CAS  Google Scholar 

  13. Chittezhath, M. et al. Immunity 41, 815–829 (2014).

    Article  CAS  Google Scholar 

  14. Misharin, A.V. et al. Cell Rep. 9, 591–604 (2014).

    Article  CAS  Google Scholar 

  15. Courties, G. et al. J. Am. Coll. Cardiol. 63, 1556–1566 (2014).

    Article  CAS  Google Scholar 

  16. Hoeksema, M.A. et al. EMBO Mol. Med. 6, 1124–1132 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philip R Taylor.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liddiard, K., Taylor, P. Understanding Local Macrophage Phenotypes In Disease: Shape-shifting macrophages. Nat Med 21, 119–120 (2015). https://doi.org/10.1038/nm.3798

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3798

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing