Macrophages are responsive to local tissue signals and alter their phenotypes accordingly. In disease tissues this means that macrophage phenotypes may change with disease progression, exacerbating or facilitating the resolution of the pathology.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice
Nature Communications Open Access 13 February 2023
-
On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells
Scientific Reports Open Access 04 November 2020
-
Bone marrow-derived Ly6C− macrophages promote ischemia-induced chronic kidney disease
Cell Death & Disease Open Access 29 March 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Murray, P.J. et al. Immunity 41, 14–20 (2014).
Davies, L.C., Jenkins, S.J., Allen, J.E. & Taylor, P.R. Nat. Immunol. 14, 986–995 (2013).
Okabe, Y. & Medzhitov, R. Cell 157, 832–844 (2014).
Rosas, M. et al. Science 344, 645–648 (2014).
Gosselin, D. et al. Cell 159, 1327–1340 (2014).
Lavin, Y. et al. Cell 159, 1312–1326 (2014).
Qian, B.Z. & Pollard, J.W. Cell 141, 39–51 (2010).
Sica, A. & Mantovani, A. J. Clin. Invest. 122, 787–795 (2012).
Lewis, C.E. & Pollard, J.W. Cancer Res. 66, 605–612 (2006).
Movahedi, K. et al. Cancer Res. 70, 5728–5739 (2010).
Franklin, R.A. et al. Science 344, 921–925 (2014).
Wang, Y.C. et al. Cancer Res. 70, 4840–4849 (2010).
Chittezhath, M. et al. Immunity 41, 815–829 (2014).
Misharin, A.V. et al. Cell Rep. 9, 591–604 (2014).
Courties, G. et al. J. Am. Coll. Cardiol. 63, 1556–1566 (2014).
Hoeksema, M.A. et al. EMBO Mol. Med. 6, 1124–1132 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Liddiard, K., Taylor, P. Understanding Local Macrophage Phenotypes In Disease: Shape-shifting macrophages. Nat Med 21, 119–120 (2015). https://doi.org/10.1038/nm.3798
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3798
This article is cited by
-
Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice
Nature Communications (2023)
-
Macrophage functional diversity in NAFLD — more than inflammation
Nature Reviews Endocrinology (2022)
-
Mechanisms and modulation of sepsis-induced immune dysfunction in children
Pediatric Research (2022)
-
On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells
Scientific Reports (2020)
-
Bone marrow-derived Ly6C− macrophages promote ischemia-induced chronic kidney disease
Cell Death & Disease (2019)