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Rheumatoid arthritis

The multifaceted role of adiponectin in inflammatory joint disease

Nature Reviews Rheumatology volume 5, pages 659–660 (2009)Cite this article

Adipocytokines are usually regarded as signaling molecules that originate from and act within the adipose tissue. However, recent data show that adipocytokines, especially adiponectin, exert various functions throughout the organism that are neither unambiguously protective nor solely harmful.

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References

  1. Laurberg, T. B. et al. Plasma adiponectin in patients with active, early, and chronic rheumatoid arthritis who are steroid- and disease-modifying antirheumatic drug-naïve compared with patients with osteoarthritis and controls. J. Rheumatol. 36, 1885–1891 (2009).

    Article  CAS  Google Scholar 

  2. Giles, J. T., Allison, M., Bingham, C. O. 3rd & Scott, W. M. Jr. Adiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis. Arthritis Care Res. 61, 1248–1256 (2009).

    Article  CAS  Google Scholar 

  3. Scherer, P. E., Williams, S., Fogliano, M., Baldini, G. & Lodish, H. F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746–26749 (1995).

    Article  CAS  Google Scholar 

  4. Kadowaki, T. & Yamauchi, T. Adiponectin and adiponectin receptors. Endocrine Rev. 26, 439–451 (2005).

    Article  CAS  Google Scholar 

  5. Neumeier, M. et al. Different effects of adiponectin isoforms in human monocytic cells. J. Leukoc. Biol. 79, 803–808 (2006).

    Article  CAS  Google Scholar 

  6. Bruun, J. M. et al. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am. J. Physiol. Endocrinol. Metab. 285, E527–E533 (2003).

    Article  CAS  Google Scholar 

  7. Trujillo, M. E. & Scherer, P. E. Adiponectin—journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J. Intern. Med. 257, 167–175 (2005).

    Article  CAS  Google Scholar 

  8. Goldstein, B. J. & Scalia, R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J. Clin. Endocrinol. Metab. 89, 2563–2568 (2004).

    Article  CAS  Google Scholar 

  9. Ehling, A. et al. The potential of adiponectin in driving arthritis. J. Immunol. 176, 4468–4478 (2006).

    Article  CAS  Google Scholar 

  10. Luo, X. H. et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J. Bone Miner. Res. 21, 1648–1656 (2006).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine and Rheumatology, and Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim, Germany

    Ulf Müller-Ladner & Elena Neumann

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  1. Ulf Müller-Ladner
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  2. Elena Neumann
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Correspondence to Ulf Müller-Ladner.

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Müller-Ladner, U., Neumann, E. The multifaceted role of adiponectin in inflammatory joint disease. Nat Rev Rheumatol 5, 659–660 (2009). https://doi.org/10.1038/nrrheum.2009.232

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