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Spondyloarthritis

Is methotrexate effective in psoriatic arthritis?

Although methotrexate is the most widely used medication for psoriatic arthritis (PsA), evidence for its effectiveness is scant. The recent MIPA trial failed to show disease-modifying effects. Was this outcome due to true inefficacy, or to trial issues? Data on symptom-modulating and disease-modifying effects of methotrexate in PsA are explored.

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The author declares that he has worked as a consultant, been a member of speakers' bureau and received grant or research support from Abbott, Amgen, Biogen Idec, Bristol–Myers Squibb, Genentech, Lilly, Pfizer and UCB. He also declares that he has worked as a consultant or received grant or research support from Celgene, Novartis and Merck.

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Mease, P. Is methotrexate effective in psoriatic arthritis?. Nat Rev Rheumatol 8, 251–252 (2012). https://doi.org/10.1038/nrrheum.2012.56

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