Original InvestigationCardiovascular and cerebrovascular morbidity and mortality among women with end-stage renal disease attributable to lupus nephritis*,**
Section snippets
Data
Data used in this study were those of the USRDS. The USRDS has collected information on all patients in the United States who have received Medicare-reimbursed maintenance renal replacement therapy since 1977.44 This database is estimated to include approximately 94% of the patients who receive renal replacement therapy in the United States. Patients must be receiving chronic dialysis therapy or have undergone renal transplantation to be included in this database.
This longitudinal database
Results
Women with ESRD caused by lupus nephritis comprised 2.0% of the study group undergoing dialysis (n = 3,431) and 5.0% of the study group that had received a renal transplant (n = 946). Compared with women with ESRD caused by diabetes mellitus and women with ESRD from other causes, women with ESRD caused by lupus nephritis were significantly younger (Table 1).
Empty Cell Lupus Nephritis Diabetes Mellitus Other Causes P On dialysis No. of
Discussion
In this study, women with ESRD caused by lupus nephritis had rates of hospitalizations for acute myocardial infarction and cerebrovascular accident similar to those of women with ESRD from causes other than diabetes mellitus or lupus nephritis. This similarity held during periods of dialysis and after renal transplantation. Deaths from these conditions did not occur more commonly among women with ESRD caused by lupus nephritis. Conversely, risks for both hospitalization and death from acute
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Cited by (47)
Incidence of Kidney Replacement Therapy and Subsequent Outcomes Among Patients With Systemic Lupus Erythematosus: Findings From the ERA Registry
2022, American Journal of Kidney DiseasesCitation Excerpt :Although SLE has been shown to be among important nontraditional risk factors of CV disease, we found no difference in CV mortality in patients with SLE receiving KRT compared with matched non-SLE patients. Comparable CV morbidity measured by hospitalization rate in SLE patients receiving KRT was observed by Ward,29 suggesting that SLE might not increase the risk of CV complications beyond the CV risk of patients receiving KRT in general. This notion could in part be explained by “burned-out” SLE in patients receiving dialysis,30,31 whereby SLE does not contribute to an inflammatory environment that could enhance the progression of atherosclerosis.
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2018, Dubois' Lupus Erythematosus and Related SyndromesESKD, Transplantation, and Dialysis in Lupus Nephritis
2015, Seminars in NephrologyCitation Excerpt :Kidney transplantation is the treatment of choice when LN patients progress to ESKD.24–26 Morbidity and mortality are substantially lower among patients who receive kidney transplantation compared with supportive dialysis.7 Although worse outcomes have been reported in LN recipients compared with diabetic recipients who received kidneys from deceased donors,27 the overall registry data from the USRDS and the United Network for Organ Sharing (UNOS) consistently have shown similar outcomes between LN recipients and the general transplant population.24,28
Relation of carotid intima-media thickness and plaque with incident cardiovascular events in women with systemic lupus erythematosus
2013, American Journal of CardiologySpecialized Treatment Approaches and Niche Therapies for Lupus Subsets
2012, Dubois' Lupus Erythematosus and Related Syndromes: Eighth Edition
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Supported in part by the Maudie Long Gift Fund at the Veterans Affairs Palo Alto Health Care System.
- **
Address reprint requests to Michael M. Ward, MD, VA Palo Alto Health Care System 111G, 3801 Miranda Ave, Palo Alto, CA 94305. E-mail: [email protected].