Chest
Selected ReportsEarly Onset Sarcoidosis with Pulmonary Function Abnormalities
Section snippets
CASE REPORT
The patient is a four-and-one-half-year-old white boy who was apparently well until, at age two and one-half years, his mother noted a progressive, nonpruritic, pink, maculopapular rash covering most areas of his body. The lesions were unresponsive to topical steroid therapy. Since the age of three and one-half years the boy has had intermittent ankle and knee swelling without subjective complaints.
Physical examination revealed a four-and-one-half-year-old boy who was 100 cm tall (third
DISCUSSION
Sarcoidosis is a chronic, multisystem disease of unknown etiology and pathogenesis that has been infrequently reported in children less than four years of age. Since constitutional symptoms such as fever, anorexia, weight loss and cough are not prominent findings in the very young child with sarcoidosis, the disease is detected at a considerably later stage and may play a role in the apparent rarity of sarcoidosis in this age group.1 The early involvement of the skin, joints and eyes produce a
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Caveats and truths in genetic, clinical, autoimmune and autoinflammatory issues in Blau syndrome and early onset sarcoidosis
2014, Autoimmunity ReviewsCitation Excerpt :Furthermore, pediatric primitive sarcoidosis resembling the most frequent adult form of sarcoidosis can also occur: in addition to eye involvement, pediatric idiopathic sarcoidosis can be revealed by more frequent lung and lymph node granulomatous inflammation. In these cases NOD2 gene analysis can exclude the genetic nature of the disease [103–105]. Due to the rarity and heterogeneity of BS and EOS there are no specific therapeutic suggestions; prospective clinical trials should be performed to identify the optimal therapy for these patients.