Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development

Immunol Cell Biol. 1999 Apr;77(2):188-93. doi: 10.1046/j.1440-1711.1999.00815.x.

Abstract

The TNF-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell-dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / immunology
  • Carrier Proteins / metabolism*
  • Embryonic and Fetal Development
  • Glycoproteins / immunology
  • Glycoproteins / metabolism*
  • Humans
  • Immune System / immunology
  • Lymph Nodes / growth & development*
  • Lymph Nodes / immunology
  • Membrane Glycoproteins / immunology
  • Membrane Glycoproteins / metabolism*
  • Osteoclasts / cytology*
  • Osteoclasts / metabolism
  • Osteoprotegerin
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • Receptors, Cytoplasmic and Nuclear*
  • Receptors, Tumor Necrosis Factor / immunology
  • Receptors, Tumor Necrosis Factor / metabolism*

Substances

  • Carrier Proteins
  • Glycoproteins
  • Membrane Glycoproteins
  • Osteoprotegerin
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Tumor Necrosis Factor
  • TNFRSF11A protein, human
  • TNFRSF11B protein, human
  • TNFSF11 protein, human