Early-morning administration of dexketoprofen-trometamol in morning stiffness induced by nodal osteoarthritis of the hands

G Rovetta; P Monteforte; A Brignone; L Molfetta; L Buffrini

Early-morning administration of dexketoprofen-trometamol in morning stiffness induced by nodal osteoarthritis of the hands

Int J Tissue React. 2001;23(2):63-6.

Authors

G Rovetta¹, P Monteforte, A Brignone, L Molfetta, L Buffrini

Affiliation

¹ Rheumatology Center, University of Genova, Bruzzone Institute, Genova, Italy.

PMID: 11447775

Abstract

Morning stiffness in osteoarthritis (OA) of the hands is a troublesome symptom that deserves attention in many OA patients. The aim of this research was to verify the action of oral dexketoprofen-trometamol (50 mg) administered early in the morning on morning stiffness in hand OA. Thirty-five patients were compared with 19 controls. The degree of morning stiffness, evaluated by means of the WOMAC scale for OA stiffness, was significantly diminished 40 min after drug administration in treated patients but not in controls. This drug acted rapidly and was effective in reducing morning stiffness in OA of the hands.

Publication types

Clinical Trial

MeSH terms

Administration, Oral
Aged
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Female
Hand
Humans
Ketoprofen / administration & dosage
Ketoprofen / analogs & derivatives*
Ketoprofen / pharmacology
Ketoprofen / therapeutic use*
Male
Middle Aged
Osteoarthritis / drug therapy*
Severity of Illness Index
Time Factors
Tromethamine / administration & dosage
Tromethamine / analogs & derivatives*
Tromethamine / pharmacology
Tromethamine / therapeutic use*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Tromethamine
Ketoprofen
dexketoprofen trometamol