Emotional ups and downs are common among people with Systemic Lupus Erythematosus (SLE) as they live with fears about treatment, pain from the illness and unexpected "flare-ups." The side effects of medications have a severe impact on their self-esteem and lead to psychological distress. This paper reports a study on the impact of a psychosocial group program on the self-esteem and psychosocial functioning of people with SLE. A total of 56 people with SLE were recruited to participate in a 6-week, 2.5-hour weekly session psychosocial group. The group served to equip members with knowledge and skills to cope with SLE and stress arising from the illness, to enhance their self-confidence and develop a positive attitude toward the illness, and to enhance their social support network. The members were assessed before the commencement and during the last session of the groups with Rosenberg's Self-esteem Inventory and General Health Questionnaire (GHQ-30). Results showed that members obtained better scores in self-esteem (p < 0.001) and GHQ (p < 0.001) after the group. The study revealed significant positive changes in self-esteem and psychosocial functioning of people with SLE after the psychosocial group program. The implications for psychosocial programs for people with SLE are discussed.