HLA-B*2709 and lack of susceptibility to sacroiliitis: further support from the clinic

A Cauli; A Vacca; G Dessole; M T Fiorillo; G Porru; V Ibba; V Mura; M Piga; R Sorrentino; A Mathieu

HLA-B*2709 and lack of susceptibility to sacroiliitis: further support from the clinic

Clin Exp Rheumatol. 2008 Nov-Dec;26(6):1111-2.

Authors

A Cauli¹, A Vacca, G Dessole, M T Fiorillo, G Porru, V Ibba, V Mura, M Piga, R Sorrentino, A Mathieu

Affiliation

¹ Department of Rheumatology, University of Cagliari, Sardinia, Italy. cauli@pacs.unica.it

PMID: 19210881

Abstract

Interferons (IFN) are well known triggers of immunomediated diseases in genetically predisposed subjects. We describe the unique case of a HLA-B*2709 positive subject who underwent IFN-alpha treatment for essential thrombocythemia and developed arthritis of the proximal interphalangeal joints of the hands but not sacroiliitis. The possible mechanisms of IFN-induced arthritis are discussed.

Publication types

Case Reports

MeSH terms

Adult
Arthritis / chemically induced*
Arthritis / genetics*
Female
Genetic Predisposition to Disease
HLA-B Antigens / genetics*
Humans
Immunologic Factors / adverse effects
Interferon-alpha / adverse effects*
Sacroiliac Joint*
Spondylitis, Ankylosing / genetics
Thrombocythemia, Essential / drug therapy*
Thrombocythemia, Essential / genetics

Substances

HLA-B Antigens
Immunologic Factors
Interferon-alpha