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The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination.
Saggau C, Martini GR, Rosati E, Meise S, Messner B, Kamps AK, Bekel N, Gigla J, Rose R, Voß M, Geisen UM, Reid HM, Sümbül M, Tran F, Berner DK, Khodamoradi Y, Vehreschild MJGT, Cornely O, Koehler P, Krumbholz A, Fickenscher H, Kreuzer O, Schreiber C, Franke A, Schreiber S, Hoyer B, Scheffold A, Bacher P. Saggau C, et al. Among authors: geisen um. Immunity. 2022 Oct 11;55(10):1924-1939.e5. doi: 10.1016/j.immuni.2022.08.003. Epub 2022 Aug 12. Immunity. 2022. PMID: 35985324 Free PMC article.
The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockade.
Geisen UM, Rose R, Neumann F, Ciripoi M, Vullriede L, Reid HM, Berner DK, Bertoglio F, Hoff P, Hust M, Longardt AC, Lorentz T, Martini GR, Saggau C, Schirmer JH, Schubert M, Sümbül M, Tran F, Voß M, Zeuner R, Morrison PJ, Bacher P, Fickenscher H, Gerdes S, Peipp M, Schreiber S, Krumbholz A, Hoyer BF. Geisen UM, et al. J Med Virol. 2022 Dec;94(12):5780-5789. doi: 10.1002/jmv.28063. Epub 2022 Aug 19. J Med Virol. 2022. PMID: 35945627 Free PMC article.
Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapies.
Geisen UM, Sümbül M, Tran F, Berner DK, Reid HM, Vullriede L, Ciripoi M, Longardt AC, Hoff P, Morrison PJ, Schneider VE, Zeuner R, Schirmer JH, Steinbach A, Nikolaus S, Gerdes S, Schreiber S, Bacher P, Hoyer BF. Geisen UM, et al. RMD Open. 2021 Dec;7(3):e002008. doi: 10.1136/rmdopen-2021-002008. RMD Open. 2021. PMID: 34880128 Free PMC article.
Limited antibody response after BA.4-5 adapted booster vaccination in rheumatic patients receiving anti-TNF therapy: Results of a case series.
Geisen UM, Voß M, Rose R, Neumann F, Bäumler C, Müller S, Paltzow L, Christophersen CM, Münier M, Hildebrand E, Hoff P, Longardt AC, Lorentz T, Schirmer JH, Sümbül M, Tran F, Berner D, Fickenscher H, Gerdes S, Schreiber S, Krumbholz A, Hoyer BF. Geisen UM, et al. J Med Virol. 2023 Dec;95(12):e29263. doi: 10.1002/jmv.29263. J Med Virol. 2023. PMID: 38112071 No abstract available.
Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort.
Geisen UM, Berner DK, Tran F, Sümbül M, Vullriede L, Ciripoi M, Reid HM, Schaffarzyk A, Longardt AC, Franzenburg J, Hoff P, Schirmer JH, Zeuner R, Friedrichs A, Steinbach A, Knies C, Markewitz RD, Morrison PJ, Gerdes S, Schreiber S, Hoyer BF. Geisen UM, et al. Ann Rheum Dis. 2021 Oct;80(10):1306-1311. doi: 10.1136/annrheumdis-2021-220272. Epub 2021 Mar 24. Ann Rheum Dis. 2021. PMID: 33762264 Free PMC article.