User profiles for "author:Andrew Filer"

Andrew Filer

The University of Birmingham
Verified email at bham.ac.uk
Cited by 15732

A stromal address code defined by fibroblasts

G Parsonage, AD Filer, O Haworth, GB Nash… - Trends in …, 2005 - cell.com
To navigate into and within tissues, leukocytes require guidance cues that enable them to
recognize which tissues to enter and which to avoid. Such cues are partly provided at the …

Synovial tissue research: a state-of-the-art review

C Orr, E Vieira-Sousa, DL Boyle, MH Buch… - Nature Reviews …, 2017 - nature.com
The synovium is the major target tissue of inflammatory arthritides such as rheumatoid
arthritis. The study of synovial tissue has advanced considerably throughout the past few …

The fibroblast as a therapeutic target in rheumatoid arthritis

A Filer - Current opinion in pharmacology, 2013 - Elsevier
Significant advances have been made in the last 5 years that have finally allowed
investigators to start targeting stromal cells such as fibroblasts in inflammatory disease …

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

S Alivernini, L MacDonald, A Elmesmari, S Finlay… - Nature medicine, 2020 - nature.com
Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

DA Rao, MF Gurish, JL Marshall, K Slowikowski… - Nature, 2017 - nature.com
CD4+ T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4+ T …

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

F Zhang, K Wei, K Slowikowski, CY Fonseka… - Nature …, 2019 - nature.com
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …

Distinct fibroblast subsets drive inflammation and damage in arthritis

AP Croft, J Campos, K Jansen, JD Turner, J Marshall… - Nature, 2019 - nature.com
The identification of lymphocyte subsets with non-overlapping effector functions has been
pivotal to the development of targeted therapies in immune-mediated inflammatory diseases …

CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts

A Chan, DL Hong, A Atzberger… - The Journal of …, 2007 - journals.aai.org
Human NK cells are divided into CD56 bright CD16− cells and CD56 dim CD16+ cells. We
tested the hypothesis that CD56 bright NK cells can differentiate into CD56 dim cells by …

[HTML][HTML] Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

F Mizoguchi, K Slowikowski, K Wei, JL Marshall… - Nature …, 2018 - nature.com
Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate
tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic …

[PDF][PDF] Nonclassical Ly6C− monocytes drive the development of inflammatory arthritis in mice

AV Misharin, CM Cuda, R Saber, JD Turner, AK Gierut… - Cell reports, 2014 - cell.com
Different subsets and/or polarized phenotypes of monocytes and macrophages may play
distinct roles during the development and resolution of inflammation. Here, we demonstrate …