There is increasing amount of evidence pointing toward a high prevalence of psychiatric
conditions among individuals with hypermobile type of Ehlers–Danlos syndrome …

Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the
skin and internal organs, and vasculopathy. SSc may be associated with high morbidity and …

During the COVID-19 pandemic, the need to provide high-level care for a large number of
patients with COVID-19 has affected resourcing for, and limited the routine care of, all other …

Due to the rarity of relapsing polychondritis (RP), many unmet needs remain in the
management of RP. Here, we present a systematic review of clinical practice guidelines …

Immunoglobulin G4-related diseases (IgG4-RD) are a group of chronic relapsing–remitting
inflammatory conditions, characterised by tissue infiltration with lymphocytes and IgG4 …

In order to address the main challenges related to the rare diseases (RDs) the European
Commission launched the European Reference Networks (ERNs), virtual networks involving …

Objective To report the effort of the European Reference Network for Rare and Complex
CONnective tissue and musculoskeletal diseases NETwork working group on Ehlers-Danlos …

The vast majority of reported (likely) pathogenic missense variants in the genes coding for
the fibrillar collagens leads to the substitution of one of the obligatory glycine residues in the …

Introduction The European Reference Network (ERN) ReCONNET is the ERN aimed at
improving the management of rare and complex connective tissue and musculoskeletal …

Background Vaccination is one of the most important measures to contain the COVID-19
pandemic, especially for frail patients. VACCINATE is a multicentre prospective …