Background Sepsis and severe focal infections represent a substantial disease burden in
children admitted to hospital. We aimed to understand the burden of disease and outcomes …

Question Which is the best strategy to achieve (drug-free) inactive disease in juvenile
idiopathic arthritis (JIA)? Methods In a randomised, single-blinded, study in disease …

Remission can be achieved and sustained in (some) JIA patients, regardless of initial
treatment. Cornerstone principles in the management of nonsystemic JIA treatment are early …

Multisystem inflammatory syndrome in children is a rare, potentially life-threatening
postinfectious complication in children after severe acute respiratory syndrome coronavirus …

Objectives. To evaluate differences in baseline characteristics between etanercept-and
adalimumab-treated JIA patients and to reveal factors that influence the choice between …

Objectives Clinical phenotyping and predicting treatment responses in SLE patients is
challenging. Extensive blood transcriptional profiling has identified various gene modules …

Design: Rabies vaccine was used as a T-cell-dependent neoantigen to investigate several
aspects of the primary and booster immune response in vivo in HIV-infected individuals …

Background The aim of this study was to compare pain-scores in three targeted treatment-
strategies in JIA-patients and to identify characteristics predicting persistent pain. Methods In …

Over the past decades, the intestinal microbiota has increasingly gained attention in studies
addressing the pathophysiology of (pediatric) autoimmune diseases, including inflammatory …

Background aims Infusion of mesenchymal stromal cells (MSCs) has been reported to be an
effective treatment modality for acute graft-versus-host disease, and MSCs have been …