Oleate abrogates palmitate-induced lipotoxicity and proinflammatory response in human bone marrow-derived mesenchymal stem cells and osteoblastic cells

C Gillet, D Spruyt, S Rigutto, A Dalla Valle… - …, 2015 - academic.oup.com
Osteoporosis is a metabolic bone disease associated with unequilibrated bone remodeling
resulting from decreased bone formation and/or increased bone resorption, leading to …

Decreased pool of mesenchymal stem cells is associated with altered chemokines serum levels in atrophic nonunion fractures

M Mathieu, S Rigutto, A Ingels, D Spruyt, N Stricwant… - Bone, 2013 - Elsevier
Nonunion fractures can cause severe dysfunction and are often difficult to treat mainly due to
a poor understanding of their physiopathology. Although many aspects of impaired fracture …

Osteonecrosis of the femoral head: lipotoxicity exacerbation in MSC and modifications of the bone marrow fluid

C Gillet, A Dalla Valle, N Gaspard, D Spruyt… - …, 2017 - academic.oup.com
Osteonecrosis of the femoral head (ON) is a multifactorial bone disease that can evolve to a
progressive destruction of the hip joint. Different pathogenic processes have been proposed …

Serum calprotectin (S100A8/A9): A promising biomarker in diagnosis and follow-up in different subgroups of juvenile idiopathic arthritis

C La, PQ Lê, A Ferster, L Goffin, D Spruyt… - RMD open, 2021 - rmdopen.bmj.com
Introduction In the management of juvenile idiopathic arthritis (JIA), there is a lack of
diagnostic and prognostic biomarkers. This study assesses the use of serum calprotectin …

[HTML][HTML] Induction of stearoyl-CoA 9-desaturase 1 protects human mesenchymal stromal cells against palmitic acid-induced lipotoxicity and inflammation

A Dalla Valle, P Vertongen, D Spruyt… - Frontiers in …, 2019 - frontiersin.org
In bone diseases such as osteonecrosis and osteoporosis, a shift toward a preferential
differentiation of mesenchymal stromal cells (MSC) into adipocytes at the expense of the …

Antibodies against carbamylated proteins: prevalence and associated disease characteristics in Belgian patients with rheumatoid arthritis or other rheumatic diseases

P Sidiras, D Spruyt, V Gangji, V Imbault… - Scandinavian journal …, 2021 - Taylor & Francis
Objectives: Anti-carbamylated protein antibodies (anti-CarP) are reported to be associated
with increased disease activity and with more severe joint damage in rheumatoid arthritis …

Place du dosage de la calprotectine sérique comme biomarqueur d'intérêt dans l'arthrite juvénile idiopathique

C La, P Stordeur, J Smet, D Franchimont… - Revue du …, 2016 - Elsevier
Nous manquons pour l'arthrite juvénile idiopathique (AJI) de marqueurs spécifiques de
diagnostic, de pronostic ou de réponse thérapeutique. La calprotectine est une protéine …

[CITATION][C] Bone and bone marrow; interactions

D Spruyt, C Gillet, J Rasschaert - Encyclopedia of Endocrine …, 2018 - difusion.ulb.ac.be

[CITATION][C] Oleic acid protects hMSC from healthy donors and osteonecrotic patients against lipotoxicity by inducing intracellular lipid droplet formation and …

C Gillet, D Spruyt, J Berlier… - JOURNAL OF …, 2014 - … ST, HOBOKEN 07030-5774, NJ USA