Potential approaches to reverse or repair renal fibrosis

D Tampe, M Zeisberg - Nature Reviews Nephrology, 2014 - nature.com
The concept of reversing chronic kidney disease (CKD) has been intensively researched
over the past decade. Indeed, as the prevalence of end-stage renal disease is constantly on …

[PDF][PDF] Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

Y Chen, S Yang, J Tavormina, D Tampe, M Zeisberg… - Cancer Cell, 2022 - cell.com
In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts,
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …

[PDF][PDF] Epigenetic reprogramming of cancer-associated fibroblasts deregulates glucose metabolism and facilitates progression of breast cancer

LM Becker, JT O'Connell, AP Vo, MP Cain, D Tampe… - Cell reports, 2020 - cell.com
The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer
progression remain to be fully understood. While altered glucose metabolism in CAFs could …

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

H Sugimoto, VS LeBleu, D Bosukonda, P Keck… - Nature medicine, 2012 - nature.com
Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as
bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation …

Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis

B Tampe, D Tampe, CA Müller… - Journal of the …, 2014 - journals.lww.com
Methylation of CpG island promoters is an epigenetic event that can effectively silence
transcription over multiple cell generations. Hypermethylation of the Rasal1 promoter …

[HTML][HTML] Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression

B Tampe, U Steinle, D Tampe, JL Carstens, P Korsten… - Kidney international, 2017 - Elsevier
Acute kidney injury (AKI) and progressive chronic kidney disease (CKD) are intrinsically tied
syndromes. In this regard, the acutely injured kidney often does not achieve its full …

[HTML][HTML] Induction of Tet3-dependent epigenetic remodeling by low-dose hydralazine attenuates progression of chronic kidney disease

B Tampe, D Tampe, EM Zeisberg, GA Müller… - …, 2015 - thelancet.com
Progression of chronic kidney disease remains a principal problem in clinical nephrology
and there is a pressing need for novel therapeutics and biomarkers. Aberrant promoter CpG …

[HTML][HTML] Immunoadsorption therapy in patients with multiple sclerosis with steroid-refractory optical neuritis

MJ Koziolek, D Tampe, M Bähr, H Dihazi… - Journal of …, 2012 - Springer
Background In multiple sclerosis relapses refractory to intravenous corticosteroid therapy,
plasma exchange is recommended. Immunoadsorption (IA) is regarded as an alternative …

Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

KK Mahadevan, VS LeBleu, EV Ramirez, Y Chen, B Li… - Developmental cell, 2023 - cell.com
Summary Oncogenic KRAS G12D (KRAS∗) is critical for the initiation and maintenance of
pancreatic ductal adenocarcinoma (PDAC) and is a known repressor of tumor immunity …

[HTML][HTML] Comparative histological subtyping of immune cell infiltrates in MPO-ANCA and PR3-ANCA glomerulonephritis

S Hakroush, D Tampe, P Ströbel, P Korsten… - Frontiers in …, 2021 - frontiersin.org
Background Acute kidney injury (AKI) is a common and severe complication of anti-
neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), potentially leading to …