The deleterious effects of chronic stress on health and its contribution to the development of
mental illness attract broad attention worldwide. An important development in the last few …

Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

Abstract Purpose of Review Stress has long been suspected to be interrelated to
(abdominal) obesity. However, interindividual differences in this complex relationship exist …

BACKGROUND: The most consistent biological finding in patients with depression is a
hyperactivity of the hypothalamic–pituitary–adrenal (HPA)-axis, which might be caused by …

Summary objective Sensitivity to glucocorticoids differs between individuals, partially due to
genetic variation in the glucocorticoid receptor (GR) gene. We studied the sequence …

We investigated whether a polymorphism in codons 22 and 23 of the glucocorticoid (GC)
receptor gene [GAGAGG (GluArg)→ GAAAAG (GluLys)] is associated with altered GC …

Chronic dysregulation of hypothalamus-pituitary-adrenal axis activity is related to several
stress-related disorders. Evidence suggests that polymorphisms in the glucocorticoid …

INTRODUCTION: Elevated levels of cortisol are known to induce various symptoms and
diseases, eg abdominal obesity, type 2 diabetes, osteoporosis and cardiovascular disease …

Glucocorticoids regulate many physiological processes and have an essential role in the
systemic response to stress. For example, gene transcription is modulated by the …

The glucocorticoid receptor (GR) is crucial for the effects of glucocorticoids (GCs). Several
polymorphisms of the GR are associated with altered sensitivity to GCs. For the ER22/23EK …