Synthesis and SAR of a New Series of COX-2-Selective Inhibitors: Pyrazolo[1,5-a]pyrimidines
C Almansa, AF de Arriba, FL Cavalcanti… - Journal of medicinal …, 2001 - ACS Publications
The synthesis and pharmacological activity of a series of bicyclic pyrazolo [1, 5-a]
pyrimidines as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The …
pyrimidines as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The …
First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo …
BA Pons-Estel, E Bonfa, ER Soriano… - Annals of the …, 2018 - ard.bmj.com
Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease,
represents a significant challenge for both diagnosis and treatment. Patients with SLE in …
represents a significant challenge for both diagnosis and treatment. Patients with SLE in …
Synthesis and structure− activity relationship of a new series of COX-2 selective inhibitors: 1, 5-diarylimidazoles
The synthesis and the pharmacological activity of a series of 1, 5-diarylimidazoles
developed as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The …
developed as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The …
Synthesis and Structure−Activity Relationship of a New Series of Potent AT1 Selective Angiotensin II Receptor Antagonists: 5-(Biphenyl-4-ylmethyl)pyrazoles
C Almansa, LA Gómez, FL Cavalcanti… - Journal of medicinal …, 1997 - ACS Publications
The synthesis and pharmacological activity of a new series of 5-(biphenyl-4-ylmethyl)
pyrazoles as potent angiotensin II antagonists both in vitro (binding of [3H] AII) and in vivo …
pyrazoles as potent angiotensin II antagonists both in vitro (binding of [3H] AII) and in vivo …
[HTML][HTML] Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations
T Maes, C Mascaró, D Rotllant, MMP Lufino… - PLoS …, 2020 - journals.plos.org
Transcription disequilibria are characteristic of many neurodegenerative diseases. The
activity-evoked transcription of immediate early genes (IEGs), important for neuronal …
activity-evoked transcription of immediate early genes (IEGs), important for neuronal …
Anti-malarials exert a protective effect while Mestizo patients are at increased risk of developing SLE renal disease: data from a Latin-American cohort
GJ Pons-Estel, GS Alarcón, L Hachuel, G Boggio… - …, 2012 - academic.oup.com
Objective. To examine the role of ethnicity and the use of anti-malarials (protective) on lupus
renal disease. Methods. A nested case–control study (1: 2 proportion, n= 265 and 530) …
renal disease. Methods. A nested case–control study (1: 2 proportion, n= 265 and 530) …
The impact of rural residency on the expression and outcome of systemic lupus erythematosus: data from a multiethnic Latin American cohort
GJ Pons-Estel, V Saurit, GS Alarcón, L Hachuel… - Lupus, 2012 - journals.sagepub.com
Objective: The objective of this paper is to examine the role of place of residency in the
expression and outcomes of systemic lupus erythematosus (SLE) in a multi-ethnic Latin …
expression and outcomes of systemic lupus erythematosus (SLE) in a multi-ethnic Latin …
Sensor network for monitoring the state of pollution of high-voltage insulators via satellite
This paper describes the design and development of a sensor system network for remote
monitoring of the state of pollution on high-voltage insulators, its deployment among four …
monitoring of the state of pollution on high-voltage insulators, its deployment among four …
Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic …
AF de Arriba, F Cavalcanti, A Miralles, Y Bayón… - Molecular …, 1999 - ASPET
The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been
emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl …
emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl …
New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs
C Almansa, J Bartrolí, J Belloc… - Journal of medicinal …, 2004 - ACS Publications
The synthesis and pharmacological evaluation of new water-soluble phosphoramidate
derivatives of the COX-2 selective inhibitor cimicoxib (4) are described. The …
derivatives of the COX-2 selective inhibitor cimicoxib (4) are described. The …