SPERMIOGENESIS is a complex process by which postmeiotic male germ cells differentiate
into mature spermatozoa. This process involves remarkable structural and biochemical …

We characterized the regulation of cyclooxygenase‐2 (COX‐2) at the mRNA, protein and
mediator level in two rat models of acute inflammation, carrageenan‐induced paw ædema …

Background: PGD2 is the major prostanoid released by mast cells during an allergic
response. Its role in the allergic response, however, remains unclear. Objective: Because …

The action of prostaglandin E2 (PGE2) in the preoptic area is thought to play an important
role in producing fever. Pharmacologic evidence suggests that, among the four subtypes of …

To gain insight into the role of prostanoids in human kidney function, we examined the
distribution of cyclooxygenase (COX) 1 and COX‐2 by immunofluorescence and …

Objective. Infliximab (IFX) is a therapeutic monoclonal antibody targeting tumor necrosis
factor-α indicated in the treatment of chronic inflammatory diseases. IFX is administered by …

Abstract Both insulin-dependent (type 1) and insulin-independent (type 2) diabetes are
complex disorders characterized by symptomatic glucose intolerance due to either defective …

Background: Prostaglandin D2 (PGD2) is released from mast cells during the allergic
response. Objective: Since PGD2 has been shown to induce nasal congestion in humans …

Objectives Subcutaneous tumour necrosis factor alpha TNFαinhibitors (SC-TNFis) such as
golimumab (GLM), adalimumab (ADA), etanercept (ETA) and certolizumab pegol (CZP) …

The CREM gene encodes both repressors and activators of cAMP-dependent transcription
in a tissue and developmentally regulated manner. In addition, multiple and cooperative …