In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

Review of mechanisms that might contribute to the fully reversible reduced immune function
that is present during hibernation. Mammalian hibernation consists of torpor phases when …

During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly,
reaching percentages of 3% annually worldwide. This increase suggests that besides …

Long term B lineage chimeras are used here to study the origin of plasma cells in the
mouse. Chlmeric mice are constructed by reconstituting lethally irradiated mice with …

Objective To assess the effect of abatacept (CTLA‐4Ig), which limits T cell activation, on
homeostasis of CD4+ T cell subsets and T cell–dependent B cell hyperactivity in patients …

Th17 cells play an important physiological role at mucosal barriers, and are involved in
inflammatory responses to pathogens. Th17 cells and their signature cytokine IL-17 are also …

Primary Sjögren's syndrome (pSS) is characterized by mononuclear inflammatory infiltrates
and IgG plasma cells in salivary and lacrimal glands which lead to irreversible destruction of …

Objective Alterations in the microbiota composition of the gastro-intestinal tract are
suspected to be involved in the etiopathogenesis of two closely related systemic …

As part of our studies into the role of germinal centers, we investigated whether each de
novo generated germinal center (GC) develops from one single GC precursor cell (GCPC …

Objective To assess the validity of ultrasound of major salivary glands (sUS) compared with
parotid and labial gland biopsies, sialometry, anti-SSA/Ro antibody status and classification …