Inflammation is a cellular and molecular response to infection and/or tissues injury. While a
suited inflammatory response in intensity and time allows for killing pathogens, clearing …

Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles
in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts …

Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function
leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we …

Ageing is characterized by a progressive loss of cellular function that leads to a decline in
tissue homeostasis, increased vulnerability and adverse health outcomes. Important …

Resident cells, such as fibroblast-like synoviocytes (FLS), play a crucial role in rheumatoid
arthritis (RA). They are implicated in the inflammatory response and play a key role in …

MicroRNAs (miRNAs) have emerged as key players in the regulation of expression of target
mRNAs expression. They have been associated with diverse biological processes, and …

Follicular helper T cells (Tfh), which play a pivotal role in B cell activation and differentiation
in lymphoid structures, secrete IL-21 whose augmented secretion is a hallmark of several …

Introduction B lymphocytes might play a pathogenic role in dermal fibrosis in systemic
sclerosis (SSc). B-cell activating factor (BAFF), a key cytokine for B-cell activation, is …

Objective To evaluate whether miR-20a belonging to the cluster miR-17–92 is a negative
regulator of inflammation in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) by …

Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic
disease of unknown origin. We investigated the contribution of the B-cell activating factor …