Pathogenesis of macrophage activation syndrome and potential for cytokine-directed therapies

GS Schulert, AA Grom - Annual review of medicine, 2015 - annualreviews.org
Macrophage activation syndrome (MAS) is an acute episode of overwhelming inflammation
characterized by activation and expansion of T lymphocytes and hemophagocytic …

Macrophage activation syndrome and cytokine-directed therapies

GS Schulert, AA Grom - Best practice & research Clinical rheumatology, 2014 - Elsevier
Macrophage activation syndrome (MAS) is an episode of overwhelming inflammation that
occurs most commonly in children with systemic juvenile idiopathic arthritis (SJIA). It is …

The genetics of macrophage activation syndrome

GS Schulert, RQ Cron - Genes & Immunity, 2020 - nature.com
Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis
(HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and …

On the alert for cytokine storm: immunopathology in COVID‐19

LA Henderson, SW Canna, GS Schulert… - Arthritis & …, 2020 - Wiley Online Library
Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …

American College of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS–CoV‐2 and Hyperinflammation in …

LA Henderson, SW Canna, KG Friedman… - Arthritis & …, 2021 - Wiley Online Library
Objective To provide guidance on the management of Multisystem Inflammatory Syndrome
in Children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …

American College of Rheumatology clinical guidance for multisystem inflammatory syndrome in children associated With SARS–CoV‐2 and hyperinflammation in …

LA Henderson, SW Canna, KG Friedman… - Arthritis & …, 2020 - Wiley Online Library
Objective To provide guidance on the management of multisystem inflammatory syndrome
in children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …

American College of Rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS–CoV‐2 and hyperinflammation in …

LA Henderson, SW Canna, KG Friedman… - Arthritis & …, 2022 - Wiley Online Library
Objective To provide guidance on the management of Multisystem Inflammatory Syndrome
in Children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …

Secretion of the Toxin ExoU Is a Marker for Highly Virulent Pseudomonas aeruginosa Isolates Obtained from Patients with Hospital-Acquired Pneumonia

GS Schulert, H Feltman, SDP Rabin… - The Journal of …, 2003 - academic.oup.com
Overall, hospital-acquired pneumonia (HAP) caused by Pseudomonas aeruginosa is
associated with high attributable mortality. Although the intrinsic virulence of P. aeruginosa …

Type III Secretion Phenotypes of Pseudomonas aeruginosa Strains Change during Infection of Individuals with Cystic Fibrosis

M Jain, D Ramirez, R Seshadri, JF Cullina… - Journal of Clinical …, 2004 - Am Soc Microbiol
Pseudomonas aeruginosa is a frequent cause of respiratory exacerbations in individuals
with cystic fibrosis. An important virulence determinant of this pathogen is its type III protein …

[HTML][HTML] Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a …

JJ Rodriguez-Smith, EL Verweyen, GM Clay… - The Lancet …, 2021 - thelancet.com
Background Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-
threatening hyperinflammatory syndrome that occurs after primary SARS-CoV-2 infection …