From NAFLD to NASH to cirrhosis—new insights into disease mechanisms
A Wree, L Broderick, A Canbay, HM Hoffman… - Nature reviews …, 2013 - nature.com
NAFLD has evolved as a serious public health problem in the USA and around the world. In
fact, NASH—the most serious form of NAFLD—is predicted to become the leading cause of …
fact, NASH—the most serious form of NAFLD—is predicted to become the leading cause of …
Neutrophils: New insights and open questions
Neutrophils are the first line of defense against bacteria and fungi and help combat parasites
and viruses. They are necessary for mammalian life, and their failure to recover after …
and viruses. They are necessary for mammalian life, and their failure to recover after …
CATERPILLERs, pyrin and hereditary immunological disorders
JPY Ting, DL Kastner, HM Hoffman - Nature Reviews Immunology, 2006 - nature.com
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is
comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This …
comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This …
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome and the leading cause of chronic liver disease in the Western world. Twenty per …
syndrome and the leading cause of chronic liver disease in the Western world. Twenty per …
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome
HM Hoffman, JL Mueller, DH Broide, AA Wanderer… - Nature …, 2001 - nature.com
Familial cold autoinflammatory syndrome (FCAS, MIM 120100), commonly known as familial
cold urticaria (FCU), is an autosomal-dominant systemic inflammatory disease characterized …
cold urticaria (FCU), is an autosomal-dominant systemic inflammatory disease characterized …
[PDF][PDF] NF-κB restricts inflammasome activation via elimination of damaged mitochondria
Nuclear factor κB (NF-κB), a key activator of inflammation, primes the NLRP3-inflammasome
for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB, however, also prevents …
for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB, however, also prevents …
[HTML][HTML] The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
R Knöll, M Hoshijima, HM Hoffman, V Person… - Cell, 2002 - cell.com
Muscle cells respond to mechanical stretch stimuli by triggering downstream signals for
myocyte growth and survival. The molecular components of the muscle stretch sensor are …
myocyte growth and survival. The molecular components of the muscle stretch sensor are …
[PDF][PDF] The NLR gene family: a standard nomenclature
Immune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, and cryopyrin
(also known as NALP3) are members of a family characterized by the presence of a NACHT …
(also known as NALP3) are members of a family characterized by the presence of a NACHT …
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
M Lamkanfi, JL Mueller, AC Vitari, S Misaghi… - Journal of Cell …, 2009 - rupress.org
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-
1β (IL-1β) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes …
1β (IL-1β) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes …
[PDF][PDF] NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
A Wree, A Eguchi, MD McGeough, CA Pena… - …, 2014 - Wiley Online Library
Inflammasome activation plays a central role in the development of drug‐induced and
obesity‐associated liver disease. However, the sources and mechanisms of inflammasome …
obesity‐associated liver disease. However, the sources and mechanisms of inflammasome …