The family of receptors for IgG (FcγR) plays an essential role in antibody-mediated effector
functions of the immune system. However, the specific contribution of each of the FcγR …

Previously, we have demonstrated that phagocytosis of IgG1-coated particles by
macrophages in vitro is impaired by deletion of FcγRIII in mice, suggesting that IgG1 may …

Background Common variable immunodeficiency (CVID) is usually well controlled with
immunoglobulin substitution and immunomodulatory drugs. A subgroup of patients has a …

We have constructed a recombinant, fully human IgA1 monoclonal antibody, UBS-54/IgA1,
against the tumor-associated Ep-CAM molecule and compared its tumor-killing capacity with …

A dysregulated immune response with hyperinflammation is observed in patients with
severe coronavirus disease 2019 (COVID-19). The aim of the present study was to assess …

Until recently, food allergies to mammalian meats have been considered to be very rare. The
observation that patients not previously exposed to the monoclonal chimeric antibody …

A single-chain Fv antibody fragment specific for the tumor-associated Ep-CAM molecule was
isolated from a semisynthetic phage display library and converted into an intact, fully human …

Human IgG receptors constitute a family of glycoprotein complexes consisting of ligand-
binding, and associated signaling chains. Three leukocyte classes (FCγRI, II, and III) and …

Studies in IL-12-deficient mice established the necessity for IL-12 to generate a Th1 cytokine
response that is often required for elimination of intracellular pathogens. In this study, we …

Background Stimulation of the immune system by targeting the PD-1/PD-L1 pathway can
result in activation of anti-tumor immunity. Besides its clinical benefit immune checkpoint …