Bone differs from other connective tissues; it is isolated by a layer of osteoblasts that are
connected by tight and gap junctions. This allows bone to create dense lamellar type I …

Antineoplastic chemotherapeutic agents may indirectly activate dendritic cells (DCs) by
inducing the release of “danger” signals from dying tumor cells. Whereas the direct cytotoxic …

Anthocyanins are a group of naturally occurring phenolic compounds widely available in
fruits and vegetables in human diets. They have broad biological activities including anti …

Breast and kidney-expressed chemokine (BRAK) CXCL14 is a new CXC chemokine with
unknown function and receptor selectivity. The majority of head and neck squamous cell …

Low estrogen levels undoubtedly underlie menopausal bone thinning. However, rapid and
profuse bone loss begins 3 y before the last menstrual period, when serum estrogen is …

We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the
femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic …

The dose-delivery schedule of conventional chemotherapy, which determines its efficacy
and toxicity, is based on the maximum tolerated dose. This strategy has lead to cure and …

Purpose: The main goal of this study was to provide the “proof-of-principle” that low-dose
paclitaxel is able to change the tumor microenvironment and improve the outcome of …

The effects of estrogen on osteoclast survival and differentiation were studied using CD14-
selected mononuclear osteoclast precursors from peripheral blood. Estradiol at∼ 1 nM …

As CD40 plays a key role in both antitumor immunity and DC maturation, we have studied
the regulation of its expression during DC hematopoiesis (dendropoiesis) in vitro and in vivo …