Background. Low back pain (LBP) is a major public health problem, often encountered in
primary care. Guidelines recommend early identification of psychosocial factors that could …

Calpains are intracellular nonlysosomal Ca2+-regulated cysteine proteases. They mediate
regulatory cleavages of specific substrates in a large number of processes during the …

Calpain 3 is a 94‐kDa calcium‐dependent cysteine protease mainly expressed in skeletal
muscle. In this tissue, it localizes at several regions of the sarcomere through binding to the …

Mutations in the Proteolytic Enzyme Calpain 3 Cause Limb-Girdle Muscular Dystrophy Type
2A Page 1 Cell, Vol. 81, 27-40, April 7, 1995, Copyright © 1995 by Cell Press Mutations in …

The limb-girdle muscular dystrophies are a genetically heterogeneous group of inherited
progressive muscle disorders that affect mainly the proximal musculature, with evidence for …

The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to
sense mechanical load. We identified a signaling complex where TK interacts with the zinc …

The limb girdle and congenital muscular dystrophies (LGMD and CMD) are characterized by
skeletal muscle weakness and dystrophic muscle changes. The onset of symptoms in CMD …

Tibial muscular dystrophy (TMD) is an autosomal dominant late-onset distal myopathy linked
to chromosome 2q31. The linked region includes the giant TTN gene, which encodes the …

Abstract β–sarcoglycan, a 43 kDa dystrophin–associated glycoprotein, is an integral
component of the dystrophin–glycoprotein complex. We have cloned human β–sarcoglycan …

MATERIALS AND METHODS Chemicals DMSO was obtained from Sigma (St Quentin
Fallavier, France).[14C] mannitol was purchased from NEN-Life Sciences (Les Ulis, France) …