Sepsis develops when the initial host response is unable to contain the primary infection,
resulting in widespread inflammation and multiple organ dysfunction. The impairment of …

Neutrophils are key effectors of the innate immune response. Reduction of neutrophil
migration to infection sites is associated with a poor outcome in sepsis. We have …

Pyruvate kinase (PK) is the enzyme responsible for catalyzing the last step of glycolysis. Of
the four PK isoforms expressed in mammalian cells, PKM2 has generated the most interest …

Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …

Sepsis is a systemic inflammatory condition following bacterial infection with a high mortality
rate and limited therapeutic options,. Here we show that interleukin-33 (IL-33) reduces …

Objective To evaluate whether the addition of colchicine to standard treatment for COVID-19
results in better outcomes. Design We present the results of a randomised, double-blinded …

Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The
primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell …

Interleukin (IL)‐33, a member of the IL‐1 cytokine family, is an important modulator of the
immune system associated with several immune‐mediated disorders. High levels of IL‐33 …

Patients with sepsis have a marked defect in neutrophil migration. Here we identify a key
role of Toll-like receptor 2 (TLR2) in the regulation of neutrophil migration and resistance …

Objectives Interleukin 33 (IL-33) is a new member of the IL-1 family of cytokines which
signals via its receptor, ST2 (IL-33R), and has an important role in Th2 and mast cell …