During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

Antibodies to citrullinated proteins (ACPA), ie, to peptides posttranslationally modified by the
conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis …

The Study Group for Risk Factors for Rheumatoid Arthritis was established by the EULAR
Standing Committee on Investigative Rheumatology to facilitate research into the preclinical …

Objective To investigate whether smoking and HLA–DR shared epitope (SE) genes may
interact in triggering immune reactions to citrulline‐modified proteins. Methods In a case …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Background Etanercept and methotrexate are effective in the treatment of rheumatoid
arthritis but no data exist on concurrent initiation or use of the combination compared with …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-
associated variants with diverse genomic and biological data sets to provide insight into …

Background Rheumatoid arthritis is a chronic inflammatory disease with a substantial
genetic component. Susceptibility to disease has been linked with a region on chromosome …

Epigenetic mechanisms integrate genetic and environmental causes of disease, but
comprehensive genome-wide analyses of epigenetic modifications have not yet …

Background Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1
and PTPN22 are well-established susceptibility loci, other genes that confer a modest level …