Patient-reported outcome (PRO) measures must provide evidence that their development
followed a rigorous process for ensuring their content validity. To this end, the collection of …

The US FDA and the European Medicines Agency (EMA) have issued incentives and laws
mandating clinical research in pediatrics. While guidances for the development and …

Ensuring adherence to therapy is a challenge in chronic diseases, particularly in cancers
such as chronic myeloid leukemia (CML), where there has been increased availability and …

Objectives. As a disease typified by early onset and chronic disease course, caring for a
person with schizophrenia may have a significant impact on caregivers' lives. This study …

Treatment of iron overload using deferoxamine (DFO) is associated with significant deficits
in patients' health-related quality of life (HRQOL) and low treatment satisfaction. The current …

Background Herpes zoster (HZ) is a painful condition that can have a substantial negative
impact on patients' lives. However, UK-specific data on the debilitating impact of HZ, in terms …

Background Atopic dermatitis (AD) is a common skin disorder characterized by chronic
inflammation, altered skin barrier function, and inflammatory cell skin infiltration that …

Background Post-herpetic neuralgia (PHN) is the most common complication of herpes
zoster (shingles). As a chronic condition, PHN can have a substantial adverse impact on …

Objectives The aim was to develop a clinical outcome assessment (COA) for itching in
children with cholestatic pruritus. Methods This prospective study aimed to enroll patients …

Purpose Major depressive disorder (MDD) has detrimental effects on health-related quality
of life (HRQoL). We describe the effect of vortioxetine on HRQoL in MDD patients by using …