Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition. Gout
typically presents as an acute, self-limiting inflammatory monoarthritis that affects the joints …

INTRODUCTION: Rheumatoid arthritis is a common inflammatory condition. A large number
of patients seek alternative or complementary therapies of which diet is an important …

Allopurinol is the most commonly prescribed urate-lowering therapy for the management of
gout. Serious adverse reactions associated with allopurinol, while rare, are feared owing to …

Objective Allopurinol is the most commonly used urate‐lowering therapy in gout. Allopurinol
hypersensitivity syndrome (AHS) is a rare but potentially fatal adverse event. Dosing …

Objective To determine the efficacy and safety of increasing the allopurinol dose above the
proposed creatinine clearance–based dose in patients with gout. Methods Patients with gout …

Objective. To determine whether MPO contributes to oxidative stress and disease activity in
RA and whether it produces hypochlorous acid in SF. Methods. Plasma and where possible …

Background The aim of this study was to compare the frequency and volume of dual energy
CT (DECT) urate deposits in people with asymptomatic hyperuricaemia and symptomatic …

Objective There is evidence supporting a therapeutic range for methotrexate polyglutamate
(MTXGlu) concentrations in the treatment of rheumatoid arthritis (RA). Knowledge of the …

Objective To determine which clinical, laboratory, and imaging features most accurately
distinguished gout from non‐gout. Methods We performed a cross‐sectional study of …

The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for HLA‐B*
58: 01 Genotype and Allopurinol Dosing was originally published in February 2013. We …