[PDF][PDF] Single-cell analysis of human mononuclear phagocytes reveals subset-defining markers and identifies circulating inflammatory dendritic cells
Human mononuclear phagocytes comprise phenotypically and functionally overlapping
subsets of dendritic cells (DCs) and monocytes, but the extent of their heterogeneity and …
subsets of dendritic cells (DCs) and monocytes, but the extent of their heterogeneity and …
[HTML][HTML] Targeting thromboinflammation in antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a systemic autoimmune disease, where persistent
presence of antiphospholipid antibodies (aPL) leads to thrombotic and obstetric …
presence of antiphospholipid antibodies (aPL) leads to thrombotic and obstetric …
Delineating the deranged immune system in the antiphospholipid syndrome
LL van den Hoogen, JAG van Roon… - Autoimmunity …, 2016 - Elsevier
The antiphospholipid syndrome (APS) is a systemic autoimmune disease that is
characterized serologically by the presence of antiphospholipid antibodies (aPL) and …
characterized serologically by the presence of antiphospholipid antibodies (aPL) and …
[HTML][HTML] B-Cells and BAFF in primary antiphospholipid syndrome, targets for therapy?
LL van den Hoogen, RJ Bisoendial - Journal of clinical medicine, 2022 - mdpi.com
Primary antiphospholipid syndrome (PAPS) is a systemic autoimmune disease
characterized by thrombosis, pregnancy morbidity, and the presence of antiphospholipid …
characterized by thrombosis, pregnancy morbidity, and the presence of antiphospholipid …
Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome
M van der Linden, LL van den Hoogen… - …, 2018 - academic.oup.com
Objectives Increased release of neutrophil extracellular traps (NETs) is implicated in the
activation of plasmacytoid dendritic cells, vascular disease and thrombosis in SLE and APS …
activation of plasmacytoid dendritic cells, vascular disease and thrombosis in SLE and APS …
[HTML][HTML] Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis
E Chouri, NH Servaas, CPJ Bekker, AJ Affandi… - Journal of …, 2018 - Elsevier
Objective MicroRNAs (miRNAs) are regulatory molecules, which have been addressed as
potential biomarkers and therapeutic targets in rheumatic diseases. Here, we investigated …
potential biomarkers and therapeutic targets in rheumatic diseases. Here, we investigated …
Galectin-9 is an easy to measure biomarker for the interferon signature in systemic lupus erythematosus and antiphospholipid syndrome
LL van den Hoogen, JAG van Roon… - Annals of the …, 2018 - ard.bmj.com
Objective The interferon (IFN) signature is related to disease activity and vascular disease in
systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) and represents …
systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) and represents …
Monocyte type I interferon signature in antiphospholipid syndrome is related to proinflammatory monocyte subsets, hydroxychloroquine and statin use
LL van den Hoogen, RDE Fritsch-Stork… - Annals of the …, 2016 - ard.bmj.com
Several autoimmune diseases, most notably systemic lupus erythematosus (SLE), show an
overexpression of type I interferon (IFN)-inducible genes, termed the IFN signature. 1 The …
overexpression of type I interferon (IFN)-inducible genes, termed the IFN signature. 1 The …
Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome
M van der Kroef, LL van den Hoogen… - European journal of …, 2020 - Wiley Online Library
Systemic sclerosis (SSc), systemic lupus erythematosus (SLE) and primary Sjögrens
syndrome (pSS) are clinically distinct systemic autoimmune diseases (SADs) that share …
syndrome (pSS) are clinically distinct systemic autoimmune diseases (SADs) that share …
microRNA downregulation in plasmacytoid dendritic cells in interferon-positive systemic lupus erythematosus and antiphospholipid syndrome
LL van den Hoogen, M Rossato, AP Lopes… - …, 2018 - academic.oup.com
Objective To investigate miRNA expression in relation to transcriptomic changes in
plasmacytoid dendritic cells (pDCs) in SLE and APS. pDCs are major producers of IFNα in …
plasmacytoid dendritic cells (pDCs) in SLE and APS. pDCs are major producers of IFNα in …