Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …

Objective To evaluate whether the addition of colchicine to standard treatment for COVID-19
results in better outcomes. Design We present the results of a randomised, double-blinded …

Background and purpose Mitochondria play a central role in the host response to viral
infection and immunity, being key to antiviral signaling and exacerbating inflammatory …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated
with a hyperinflammatory state and lymphocytopenia, a hallmark that appears as both …

The severe forms and worsened outcomes of COVID-19 (coronavirus disease 19) are
closely associated with hypertension and cardiovascular disease. Endothelial cells express …

Although SARS-CoV-2 severe infection is associated with a hyperinflammatory state,
lymphopenia is an immunological hallmark, and correlates with poor prognosis in COVID …

COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering
immunopathogenesis are not established. The functional plasticity of macrophages allows …

Introduction Neutrophilia and high levels of proinflammatory cytokines and other mediators
of inflammation are common finds in patients with severe acute respiratory syndrome due to …

Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …

The glycocalyx is a layer composed of carbohydrate side chains bound to core proteins that
lines the vascular endothelium. The integrity of the glycocalyx is essential for endothelial …