Joint distraction for osteoarthritis: clinical evidence and molecular mechanisms

MP Jansen, SC Mastbergen - Nature Reviews Rheumatology, 2022 - nature.com
Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

Knee joint distraction as treatment for osteoarthritis results in clinical and structural benefit: a systematic review and meta-analysis of the limited number of studies and …

MP Jansen, TAEJ Boymans, RJH Custers… - Cartilage, 2021 - journals.sagepub.com
Objective Knee joint distraction (KJD) is a joint-preserving osteoarthritis treatment that may
postpone a total knee arthroplasty (TKA) in younger patients. This systematic review and …

Knee joint distraction compared with high tibial osteotomy and total knee arthroplasty: two-year clinical, radiographic, and biochemical marker outcomes of two …

MP Jansen, NJ Besselink, RJ van Heerwaarden… - Cartilage, 2021 - journals.sagepub.com
Objective Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-
preserving surgeries that postpone total knee arthroplasty (TKA) in younger osteoarthritis …

Cohort profile: the applied public-private research enabling osteoarthritis clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe …

EM van Helvoort, WE van Spil, MP Jansen… - BMJ open, 2020 - bmjopen.bmj.com
Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway
(APPROACH) consortium intends to prospectively describe in detail, preselected patients …

[HTML][HTML] Knee joint distraction in regular care for treatment of knee osteoarthritis: a comparison with clinical trial data

MP Jansen, SC Mastbergen, RJ van Heerwaarden… - PLoS …, 2020 - journals.plos.org
Objectives Knee joint distraction (KJD) has been evaluated as a joint-preserving treatment to
postpone total knee arthroplasty in knee osteoarthritis patients in three clinical trials. Since …

[HTML][HTML] Relevance of biomarkers in serum vs. synovial fluid in patients with knee osteoarthritis

S Kalogera, MP Jansen, AC Bay-Jensen… - International Journal of …, 2023 - mdpi.com
The association between structural changes and pain sensation in osteoarthritis (OA)
remains unclear. Joint deterioration in OA leads to the release of protein fragments that can …

Knee joint distraction results in MRI cartilage thickness increase up to 10 years after treatment

MP Jansen, SC Mastbergen, JW MacKay… - …, 2022 - academic.oup.com
Objectives Knee joint distraction (KJD) has been shown to result in long-term clinical
improvement and short-term cartilage restoration in young OA patients. The objective of the …

Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping

EM van Helvoort, PMJ Welsing, MP Jansen… - RMD open, 2021 - rmdopen.bmj.com
Objectives Osteoarthritis (OA) patients with a neuropathic pain (NP) component may
represent a specific phenotype. This study compares joint damage, pain and functional …

Return to sport and work after randomization for knee distraction versus high tibial osteotomy: is there a difference?

A Hoorntje, PPFM Kuijer… - The journal of knee …, 2022 - thieme-connect.com
Knee joint distraction (KJD) is a novel technique for relatively young knee osteoarthritis (OA)
patients. With KJD, an external distraction device creates temporary total absence of contact …

Artificial intelligence in osteoarthritis: repair by knee joint distraction shows association of pain, radiographic and immunological outcomes

MP Jansen, C Salzlechner, E Barnes… - …, 2023 - academic.oup.com
Objectives Knee joint distraction (KJD) has been associated with clinical and structural
improvement and SF marker changes. The current objective was to analyse radiographic …